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- W2037492056 abstract "Abstract The central serotonergic neurones seem to have important regulatory function on the cardiovascular system. Since human blood platelets and serotonin (5-HT) containing neurones in the central nervous system have numerous similarities, the uptake of serotonin by human platelets was investigated in normal subjects and in patients of essential hypertension. The 5-HT content of platelets as well as 5-HT uptake by the platelets were significantly reduced in hypertensive subjects as compared to control. It appears that a deficiency of serotonin centrally may lead to disinhibition of the serotonergic mechanisms leading to hypertension. Moreover, a decreased activity of serotonergic neurones may co-exist with an over-activity of catecholaminergic neurones in essential hypertension, which is discussed. This is probably the first report of altered serotonin mechanism in clinical hypertension." @default.
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- W2037492056 date "1979-07-01" @default.
- W2037492056 modified "2023-09-26" @default.
- W2037492056 title "Uptake of serotonin by human platelets and its relevance to CNS involvement in hypertension" @default.
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- W2037492056 doi "https://doi.org/10.1016/0024-3205(79)90391-6" @default.
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