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• W2037492723 startingPage "425" @default.
• W2037492723 abstract "Mammalian preimplantation embryos develop in the oviduct as individual entities, and can develop and survive in vitro, in defined culture media lacking exogenous growth factors or serum. Therefore, early embryos must generate intrinsic signals that promote their development and survival. In other cells, activation of class I phosphoinositide 3-kinase (PI3K) is a universal mechanism to promote cell proliferation and survival. Here, we examined whether PI3K is intrinsically activated during preimplantation development. Using GFP-tagged pleckstrin homology domains to monitor PtdIns(3,4,5)P(3) synthesis, we show that PI3K is constitutively activated in mouse preimplantation embryos. E-cadherin ligation promotes PtdIns(3,4,5)P(3) synthesis at sites of blastomere adhesion at all cleavage stages. In addition, in culture conditions that promote autocrine signalling, a second pool of PtdIns(3,4,5)P(3) is generated in the apical membrane of early stage blastomeres. We show that constitutive PtdIns(3,4,5)P(3) synthesis is necessary for optimal development to blastocyst and to prevent large-scale apoptosis at the time of cavitation." @default.
• W2037492723 created "2016-06-24" @default.
• W2037492723 creator A5008040877 @default.
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• W2037492723 date "2008-02-01" @default.
• W2037492723 modified "2023-10-17" @default.
• W2037492723 title "Constitutive PtdIns(3,4,5)<i>P</i>3 synthesis promotes the development and survival of early mammalian embryos" @default.
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• W2037492723 doi "https://doi.org/10.1242/dev.014894" @default.
• W2037492723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18094023" @default.
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