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- W2037493669 abstract "Acridine derivatives have been explored as DNA-binding anticancer agents. Some derivatives show undesired pharmacokinetic properties and new derivatives need to be explored. In this work, a series of novel acridine analogues were synthesized by modifying previously unexplored linkers between the acridine and benzene groups and their antiproliferative activity and the DNA-binding ability were evaluated. Among these derivatives, compound 5c demonstrated DNA-binding capability and topoisomerase I inhibitory activity. In K562 cell lines, 5c induced apoptosis through mitochondria-dependent intrinsic pathways. These data suggested that compound 5c and other acridine derivatives with modified linkers between the acridine and benzene groups might be potent DNA-binding agents." @default.
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- W2037493669 date "2013-07-01" @default.
- W2037493669 modified "2023-10-15" @default.
- W2037493669 title "Novel synthetic acridine derivatives as potent DNA-binding and apoptosis-inducing antitumor agents" @default.
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- W2037493669 doi "https://doi.org/10.1016/j.bmc.2013.05.008" @default.
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