FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037497739> ?p ?o ?g. }

• W2037497739 endingPage "1544" @default.
• W2037497739 startingPage "1538" @default.
• W2037497739 abstract "China is regarded by the World Health Organization as a major hot-spot region for Mycobacterium tuberculosis infection. Streptomycin has been deployed in China for over 50 years and is still widely used for tuberculosis treatment. We have developed a denaturing HPLC (DHPLC) method for detecting various gene mutations conferring drug resistance in M. tuberculosis. The present study focused on rpsL and rrs mutation analysis. Two hundred and fifteen M. tuberculosis clinical isolates (115 proved to be streptomycin-resistant and 100 susceptible by a routine proportional method) from China were tested to determine the streptomycin minimal inhibitory concentration (MIC), and subjected to DHPLC and concurrent DNA sequencing to determine rpsL and rrs mutations. The results showed that 85.2% (98/115) of streptomycin-resistant isolates harbored rpsL or rrs mutation, while rpsL mutation (76.5%, 88/115) dominated. MIC of 98 mutated isolates revealed no close correlation between mutation types and levels of streptomycin resistance. No mutation was found in any of the susceptible isolates. The DHPLC results were completely consistent with those of sequencing. The DHPLC method devised in this study can be regarded as a useful and powerful tool for detection of streptomycin resistance. This is the first report to describe DHPLC analysis of mutations in the rpsL and rrs genes of M. tuberculosis in a large number of clinical isolates." @default.
• W2037497739 created "2016-06-24" @default.
• W2037497739 creator A5011662582 @default.
• W2037497739 creator A5043270589 @default.
• W2037497739 creator A5051979736 @default.
• W2037497739 creator A5070630661 @default.
• W2037497739 creator A5084915949 @default.
• W2037497739 date "2007-11-01" @default.
• W2037497739 modified "2023-10-14" @default.
• W2037497739 title "Detection of streptomycin resistance in Mycobacterium tuberculosis clinical isolates from China as determined by denaturing HPLC analysis and DNA sequencing" @default.
• W2037497739 cites W1971706644 @default.
• W2037497739 cites W1975045527 @default.
• W2037497739 cites W1983951959 @default.
• W2037497739 cites W1997107662 @default.
• W2037497739 cites W2008858822 @default.
• W2037497739 cites W2010731297 @default.
• W2037497739 cites W2013395052 @default.
• W2037497739 cites W2018110831 @default.
• W2037497739 cites W2018591582 @default.
• W2037497739 cites W2077771475 @default.
• W2037497739 cites W2099499236 @default.
• W2037497739 cites W2108226494 @default.
• W2037497739 cites W2112687806 @default.
• W2037497739 cites W2119603196 @default.
• W2037497739 cites W2126754090 @default.
• W2037497739 cites W2127531034 @default.
• W2037497739 cites W2137619594 @default.
• W2037497739 cites W2142050238 @default.
• W2037497739 cites W2151636105 @default.
• W2037497739 cites W2151708720 @default.
• W2037497739 cites W2152755899 @default.
• W2037497739 cites W2164791362 @default.
• W2037497739 cites W2169423236 @default.
• W2037497739 cites W2170243611 @default.
• W2037497739 doi "https://doi.org/10.1016/j.micinf.2007.08.009" @default.
• W2037497739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18023388" @default.
• W2037497739 hasPublicationYear "2007" @default.
• W2037497739 type Work @default.
• W2037497739 sameAs 2037497739 @default.
• W2037497739 citedByCount "31" @default.
• W2037497739 countsByYear W20374977392012 @default.
• W2037497739 countsByYear W20374977392013 @default.
• W2037497739 countsByYear W20374977392014 @default.
• W2037497739 countsByYear W20374977392015 @default.
• W2037497739 countsByYear W20374977392016 @default.
• W2037497739 countsByYear W20374977392017 @default.
• W2037497739 countsByYear W20374977392018 @default.
• W2037497739 countsByYear W20374977392019 @default.
• W2037497739 countsByYear W20374977392020 @default.
• W2037497739 countsByYear W20374977392023 @default.
• W2037497739 crossrefType "journal-article" @default.
• W2037497739 hasAuthorship W2037497739A5011662582 @default.
• W2037497739 hasAuthorship W2037497739A5043270589 @default.
• W2037497739 hasAuthorship W2037497739A5051979736 @default.
• W2037497739 hasAuthorship W2037497739A5070630661 @default.
• W2037497739 hasAuthorship W2037497739A5084915949 @default.
• W2037497739 hasConcept C104317684 @default.
• W2037497739 hasConcept C114851261 @default.
• W2037497739 hasConcept C142724271 @default.
• W2037497739 hasConcept C2775843808 @default.
• W2037497739 hasConcept C2776053618 @default.
• W2037497739 hasConcept C2777975735 @default.
• W2037497739 hasConcept C2781069245 @default.
• W2037497739 hasConcept C501593827 @default.
• W2037497739 hasConcept C501734568 @default.
• W2037497739 hasConcept C54355233 @default.
• W2037497739 hasConcept C71924100 @default.
• W2037497739 hasConcept C86803240 @default.
• W2037497739 hasConcept C89423630 @default.
• W2037497739 hasConceptScore W2037497739C104317684 @default.
• W2037497739 hasConceptScore W2037497739C114851261 @default.
• W2037497739 hasConceptScore W2037497739C142724271 @default.
• W2037497739 hasConceptScore W2037497739C2775843808 @default.
• W2037497739 hasConceptScore W2037497739C2776053618 @default.
• W2037497739 hasConceptScore W2037497739C2777975735 @default.
• W2037497739 hasConceptScore W2037497739C2781069245 @default.
• W2037497739 hasConceptScore W2037497739C501593827 @default.
• W2037497739 hasConceptScore W2037497739C501734568 @default.
• W2037497739 hasConceptScore W2037497739C54355233 @default.
• W2037497739 hasConceptScore W2037497739C71924100 @default.
• W2037497739 hasConceptScore W2037497739C86803240 @default.
• W2037497739 hasConceptScore W2037497739C89423630 @default.
• W2037497739 hasIssue "14-15" @default.
• W2037497739 hasLocation W20374977391 @default.
• W2037497739 hasLocation W20374977392 @default.
• W2037497739 hasOpenAccess W2037497739 @default.
• W2037497739 hasPrimaryLocation W20374977391 @default.
• W2037497739 hasRelatedWork W1963697099 @default.
• W2037497739 hasRelatedWork W2140892120 @default.
• W2037497739 hasRelatedWork W2358903681 @default.
• W2037497739 hasRelatedWork W2373116024 @default.
• W2037497739 hasRelatedWork W2407606571 @default.
• W2037497739 hasRelatedWork W3144181501 @default.
• W2037497739 hasRelatedWork W4250274956 @default.
• W2037497739 hasRelatedWork W4291675939 @default.
• W2037497739 hasRelatedWork W652003262 @default.
• W2037497739 hasRelatedWork W913558992 @default.
• W2037497739 hasVolume "9" @default.

• next