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- W2037501064 abstract "Molecular structural characteristics of thyroid hormones which influence binding to the erythrocyte membranes were investigated by competitive binding experiments. The ability of thyroid hormone analogs to displace 131I-l-thyroxine and 131I-1-triiodothyronine from the membranes was considered evidence of their competitive binding. The diphenyl ether linkage (thyronine) was essential as compounds with a single aromatic ring were weakly competitive. The presence of three iodine atoms at 3,5 and 3′ positions on thyronine was optimal for maximal competitive binding. There was weak competitive binding of analogs if chlorine or bromine was substituted for iodine. The alanine side chain was required for optimal binding as N-acetyl-1-thyroxine and various deaminated analogs were poor competitors compared to T4 and T3. L-isomers of T4 and T3 showed greater competitive binding to erythrocyte membranes than the corresponding d-isomers." @default.
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- W2037501064 title "Interaction Between Thyroid Hormones and Erythrocyte Membranes: Competitive Inhibition of Binding<sup>131</sup>I-L-Triiodothyronine and<sup>131</sup>I-L-Thyroxine by Their Analogs" @default.
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- W2037501064 doi "https://doi.org/10.3109/07435807609052927" @default.
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