FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037523082> ?p ?o ?g. }

• W2037523082 endingPage "327" @default.
• W2037523082 startingPage "324" @default.
• W2037523082 abstract "Degradation of atracurium by Hofmann elimination and ester hydrolysis depends mainly on pH and temperature and is said to be independent of liver and kidney function. Consequently atracurium is used widely in patients with liver failure. However, there is evidence that incubation of atracurium at 37 degrees C and pH 8 leads to leakage of LDH from hepatocyte cell cultures. We have tested the hepatotoxic effects of incubated atracurium in an isolated perfused rat liver model. After equilibration, atracurium 2010 mumol ml-1 (preincubated at pH 8 and 37 degrees C for 120 min) was administered over a period of 10 min followed by perfusion of Krebs-Henseleit bicarbonate buffer for 60 min. We found that incubation resulted in considerable degradation of atracurium and formation of laudanosine. Administration of incubated atracurium did not produce either biochemical or morphological damage to liver cells, but caused considerable increase in bile flow. We conclude that administration of preincubated atracurium did not produce impairment of liver cell function. The increase in bile flow could be beneficial if it occurs clinically." @default.
• W2037523082 created "2016-06-24" @default.
• W2037523082 creator A5009266890 @default.
• W2037523082 creator A5019418738 @default.
• W2037523082 creator A5024154712 @default.
• W2037523082 creator A5032135407 @default.
• W2037523082 creator A5048168089 @default.
• W2037523082 creator A5048811350 @default.
• W2037523082 creator A5055207667 @default.
• W2037523082 date "1994-03-01" @default.
• W2037523082 modified "2023-10-01" @default.
• W2037523082 title "Influence of incubated atracurium on rat liver function" @default.
• W2037523082 cites W1979977303 @default.
• W2037523082 cites W1984498541 @default.
• W2037523082 cites W2012970268 @default.
• W2037523082 cites W2024819215 @default.
• W2037523082 cites W2025079511 @default.
• W2037523082 cites W2041698325 @default.
• W2037523082 cites W2042683599 @default.
• W2037523082 cites W2079659950 @default.
• W2037523082 cites W2092962362 @default.
• W2037523082 cites W2097834282 @default.
• W2037523082 cites W2113778151 @default.
• W2037523082 cites W2122639545 @default.
• W2037523082 cites W2137284752 @default.
• W2037523082 cites W2137700354 @default.
• W2037523082 cites W2319542136 @default.
• W2037523082 cites W2345310932 @default.
• W2037523082 cites W285339227 @default.
• W2037523082 cites W3035657388 @default.
• W2037523082 cites W3138435494 @default.
• W2037523082 cites W91288985 @default.
• W2037523082 doi "https://doi.org/10.1093/bja/72.3.324" @default.
• W2037523082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8130052" @default.
• W2037523082 hasPublicationYear "1994" @default.
• W2037523082 type Work @default.
• W2037523082 sameAs 2037523082 @default.
• W2037523082 citedByCount "8" @default.
• W2037523082 countsByYear W20375230822022 @default.
• W2037523082 countsByYear W20375230822023 @default.
• W2037523082 crossrefType "journal-article" @default.
• W2037523082 hasAuthorship W2037523082A5009266890 @default.
• W2037523082 hasAuthorship W2037523082A5019418738 @default.
• W2037523082 hasAuthorship W2037523082A5024154712 @default.
• W2037523082 hasAuthorship W2037523082A5032135407 @default.
• W2037523082 hasAuthorship W2037523082A5048168089 @default.
• W2037523082 hasAuthorship W2037523082A5048811350 @default.
• W2037523082 hasAuthorship W2037523082A5055207667 @default.
• W2037523082 hasBestOaLocation W20375230821 @default.
• W2037523082 hasConcept C126322002 @default.
• W2037523082 hasConcept C134018914 @default.
• W2037523082 hasConcept C146957229 @default.
• W2037523082 hasConcept C178790620 @default.
• W2037523082 hasConcept C185592680 @default.
• W2037523082 hasConcept C202751555 @default.
• W2037523082 hasConcept C25642318 @default.
• W2037523082 hasConcept C2776200302 @default.
• W2037523082 hasConcept C2778717843 @default.
• W2037523082 hasConcept C2781112554 @default.
• W2037523082 hasConcept C2908688231 @default.
• W2037523082 hasConcept C2909465803 @default.
• W2037523082 hasConcept C29730261 @default.
• W2037523082 hasConcept C42219234 @default.
• W2037523082 hasConcept C55493867 @default.
• W2037523082 hasConcept C71924100 @default.
• W2037523082 hasConcept C94412978 @default.
• W2037523082 hasConcept C98274493 @default.
• W2037523082 hasConceptScore W2037523082C126322002 @default.
• W2037523082 hasConceptScore W2037523082C134018914 @default.
• W2037523082 hasConceptScore W2037523082C146957229 @default.
• W2037523082 hasConceptScore W2037523082C178790620 @default.
• W2037523082 hasConceptScore W2037523082C185592680 @default.
• W2037523082 hasConceptScore W2037523082C202751555 @default.
• W2037523082 hasConceptScore W2037523082C25642318 @default.
• W2037523082 hasConceptScore W2037523082C2776200302 @default.
• W2037523082 hasConceptScore W2037523082C2778717843 @default.
• W2037523082 hasConceptScore W2037523082C2781112554 @default.
• W2037523082 hasConceptScore W2037523082C2908688231 @default.
• W2037523082 hasConceptScore W2037523082C2909465803 @default.
• W2037523082 hasConceptScore W2037523082C29730261 @default.
• W2037523082 hasConceptScore W2037523082C42219234 @default.
• W2037523082 hasConceptScore W2037523082C55493867 @default.
• W2037523082 hasConceptScore W2037523082C71924100 @default.
• W2037523082 hasConceptScore W2037523082C94412978 @default.
• W2037523082 hasConceptScore W2037523082C98274493 @default.
• W2037523082 hasIssue "3" @default.
• W2037523082 hasLocation W20375230821 @default.
• W2037523082 hasLocation W20375230822 @default.
• W2037523082 hasOpenAccess W2037523082 @default.
• W2037523082 hasPrimaryLocation W20375230821 @default.
• W2037523082 hasRelatedWork W2095581038 @default.
• W2037523082 hasRelatedWork W2326430580 @default.
• W2037523082 hasRelatedWork W2349793754 @default.
• W2037523082 hasRelatedWork W2358083755 @default.
• W2037523082 hasRelatedWork W2403182174 @default.
• W2037523082 hasRelatedWork W2439779970 @default.
• W2037523082 hasRelatedWork W2470721602 @default.
• W2037523082 hasRelatedWork W2977378907 @default.

• next