FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037532074> ?p ?o ?g. }

• W2037532074 endingPage "2472" @default.
• W2037532074 startingPage "2462" @default.
• W2037532074 abstract "Five quantitative trait loci (QTLs), Rf-1 to Rf-5, were found in Fawn-Hooded hypertensive (FHH) rats influencing susceptibility to renal damage. Previously, we found that single transfer of the Rf-1 QTL from FHH rats onto the renal-resistant August x Copenhagen Irish (ACI) strain caused a small increase in renal susceptibility. To investigate the separate role of the Rf-4 QTL and its interaction with Rf-1, we generated a single congenic strain carrying Rf-4 and a double congenic carrying both Rf-1 and Rf-4.Differences in renal susceptibility between ACI, Rf-1A, and Rf-4 single congenics and Rf-1A+4 double congenics were assessed using four different treatments: control (two-kidney), two-kidney with l-arginine analogue N-nitro-l-arginine methyl ester (L-NAME)-induced hypertension, unilateral nephrectomy, and unilateral nephrectomy + L-NAME. In separate experiments, renal blood flow (RBF) autoregulation was compared between two-kidney ACI and congenic rats.Compared to ACI, Rf-1A rats developed more renal damage, while Rf-4 rats did not. The most severe renal damage was found in the Rf-1A+4 double congenic rats. Analysis of variance (ANOVA) demonstrated a significant interaction between the Rf-1A and Rf-4 QTLs. The magnitude of the interaction varied with the type and duration of the treatment. The RBF autoregulation was impaired in Rf-1A single and Rf-1A+4 double congenics, while in Rf-4 single congenics it was similar to that of ACI controls.These findings indicate that the Rf-1 QTL directly influences renal susceptibility and autoregulation. In contrast, the Rf-4 QTL shows no direct effects, but significantly increases susceptibility to renal damage via an interaction with Rf-1." @default.
• W2037532074 created "2016-06-24" @default.
• W2037532074 creator A5000627207 @default.
• W2037532074 creator A5044647402 @default.
• W2037532074 creator A5068577442 @default.
• W2037532074 creator A5070802128 @default.
• W2037532074 creator A5074891779 @default.
• W2037532074 creator A5089682390 @default.
• W2037532074 date "2005-12-01" @default.
• W2037532074 modified "2023-10-16" @default.
• W2037532074 title "Interaction between Rf-1 and Rf-4 quantitative trait loci increases susceptibility to renal damage in double congenic rats" @default.
• W2037532074 cites W1527718000 @default.
• W2037532074 cites W1542772707 @default.
• W2037532074 cites W161222599 @default.
• W2037532074 cites W1899705152 @default.
• W2037532074 cites W1966360257 @default.
• W2037532074 cites W1995746483 @default.
• W2037532074 cites W1996008964 @default.
• W2037532074 cites W1997512772 @default.
• W2037532074 cites W2005735168 @default.
• W2037532074 cites W2042884932 @default.
• W2037532074 cites W2055082488 @default.
• W2037532074 cites W2066181453 @default.
• W2037532074 cites W2082266688 @default.
• W2037532074 cites W2097040991 @default.
• W2037532074 cites W2097748223 @default.
• W2037532074 cites W2100990796 @default.
• W2037532074 cites W2102056443 @default.
• W2037532074 cites W2107442450 @default.
• W2037532074 cites W2116885885 @default.
• W2037532074 cites W2117871749 @default.
• W2037532074 cites W2119229696 @default.
• W2037532074 cites W2124178960 @default.
• W2037532074 cites W2124768606 @default.
• W2037532074 cites W2136253087 @default.
• W2037532074 cites W2137997062 @default.
• W2037532074 cites W2139519131 @default.
• W2037532074 cites W2143428808 @default.
• W2037532074 cites W2143597881 @default.
• W2037532074 cites W2147579244 @default.
• W2037532074 cites W2148177230 @default.
• W2037532074 cites W2150989567 @default.
• W2037532074 cites W2154208078 @default.
• W2037532074 cites W2156864757 @default.
• W2037532074 cites W2157222487 @default.
• W2037532074 cites W2167596989 @default.
• W2037532074 cites W2168287443 @default.
• W2037532074 cites W2172035622 @default.
• W2037532074 cites W2177118940 @default.
• W2037532074 cites W2263641643 @default.
• W2037532074 cites W4245177871 @default.
• W2037532074 doi "https://doi.org/10.1111/j.1523-1755.2005.00722.x" @default.
• W2037532074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16316323" @default.
• W2037532074 hasPublicationYear "2005" @default.
• W2037532074 type Work @default.
• W2037532074 sameAs 2037532074 @default.
• W2037532074 citedByCount "19" @default.
• W2037532074 countsByYear W20375320742012 @default.
• W2037532074 countsByYear W20375320742013 @default.
• W2037532074 countsByYear W20375320742015 @default.
• W2037532074 countsByYear W20375320742016 @default.
• W2037532074 crossrefType "journal-article" @default.
• W2037532074 hasAuthorship W2037532074A5000627207 @default.
• W2037532074 hasAuthorship W2037532074A5044647402 @default.
• W2037532074 hasAuthorship W2037532074A5068577442 @default.
• W2037532074 hasAuthorship W2037532074A5070802128 @default.
• W2037532074 hasAuthorship W2037532074A5074891779 @default.
• W2037532074 hasAuthorship W2037532074A5089682390 @default.
• W2037532074 hasBestOaLocation W20375320741 @default.
• W2037532074 hasConcept C104317684 @default.
• W2037532074 hasConcept C126322002 @default.
• W2037532074 hasConcept C134018914 @default.
• W2037532074 hasConcept C2780091579 @default.
• W2037532074 hasConcept C2780227381 @default.
• W2037532074 hasConcept C41008148 @default.
• W2037532074 hasConcept C54355233 @default.
• W2037532074 hasConcept C71924100 @default.
• W2037532074 hasConcept C74064498 @default.
• W2037532074 hasConcept C76155785 @default.
• W2037532074 hasConcept C81941488 @default.
• W2037532074 hasConcept C84951073 @default.
• W2037532074 hasConcept C86803240 @default.
• W2037532074 hasConceptScore W2037532074C104317684 @default.
• W2037532074 hasConceptScore W2037532074C126322002 @default.
• W2037532074 hasConceptScore W2037532074C134018914 @default.
• W2037532074 hasConceptScore W2037532074C2780091579 @default.
• W2037532074 hasConceptScore W2037532074C2780227381 @default.
• W2037532074 hasConceptScore W2037532074C41008148 @default.
• W2037532074 hasConceptScore W2037532074C54355233 @default.
• W2037532074 hasConceptScore W2037532074C71924100 @default.
• W2037532074 hasConceptScore W2037532074C74064498 @default.
• W2037532074 hasConceptScore W2037532074C76155785 @default.
• W2037532074 hasConceptScore W2037532074C81941488 @default.
• W2037532074 hasConceptScore W2037532074C84951073 @default.
• W2037532074 hasConceptScore W2037532074C86803240 @default.
• W2037532074 hasIssue "6" @default.
• W2037532074 hasLocation W20375320741 @default.
• W2037532074 hasLocation W20375320742 @default.

• next