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- W2037535385 abstract "Cultured neonatal rat microglia were pretreated with varying doses of either purified interferon (IFN) α/β or recombinant IFNγ for 24 or 48 h and the following functional parameters examined; superoxide anion production, interleukin-1 secretion and chemotaxis. IFNγ produced a marked increase in superoxide anion levels when PMA was used to initiate superoxide anion production but had no effect in OPZ-stimulated microglia. Treatment with IFNα/β potentiated superoxide anion production in both PMA and OPZ-stimulated cells. Interleukin-1 activity was decreased by treatment with IFNγ for 24 h while IFNα/β increased IL-1 activity at 48 h. Removal of serum from the treatment media prevented the action of IFNα/β on IL-1 production. Treatment with IFNα/β or γ decreased chemotaxis of microglia in response to zymosan activated serum. The data indicate that IFNγ and α/β can regulate microglial function and that this regulation may differ from that seen for other monocytically derived macrophages." @default.
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- W2037535385 date "1992-09-01" @default.
- W2037535385 modified "2023-10-03" @default.
- W2037535385 title "Regulation of microglial function by interferons" @default.
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- W2037535385 doi "https://doi.org/10.1016/0165-5728(92)90216-8" @default.
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