FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037535664> ?p ?o ?g. }

• W2037535664 endingPage "51" @default.
• W2037535664 startingPage "41" @default.
• W2037535664 abstract "Vascular endothelial insulin resistance (IR) is a critically initial factor in cardiocerebrovascular events resulted from diabetes and is becoming a worldwide public health issue. Thiazolidinediones (TZDs) are clinical insulin-sensitizers acting through a canonical peroxisome proliferator-activated receptor gamma (PPARγ)-dependent insulin trans-activation pathway. However, it remains elusive whether there are other mechanisms. In current study, we investigated whether TZDs improve endothelial IR induced by high glucose concentration or hyperglycemia via a non-canonical PPARγ-dependent nuclear factor-kappa B (NF-κB) trans-repression pathway. Our results showed that pre-treatment with TZDs dramatically decrease the susceptibility of endothelial cell to IR, while post-treatment notably improve the endothelial IR both in vitro and in vivo. Moreover, TZDs substantially increase the levels of endothelial nitric oxide synthase (eNOS) and inhibitory κB alpha (IκBα), whereas decrease those of the phosphorylated inhibitory κB kinase alpha/beta (phosphor-IKKα/β) and the cytokines including tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cellular adhesion molecule-1 (sVCAM-1), suggesting that TZDs act indeed through a PPARγ-dependent NF-κB trans-repression pathway. These findings highlighted a non-canonical mechanism for TZDs to ameliorate endothelial IR which might provide a potential strategy to prevent and treat the diabetic vascular complications clinically." @default.
• W2037535664 created "2016-06-24" @default.
• W2037535664 creator A5007669734 @default.
• W2037535664 creator A5009476732 @default.
• W2037535664 creator A5012663740 @default.
• W2037535664 creator A5012949518 @default.
• W2037535664 creator A5014206663 @default.
• W2037535664 creator A5025565431 @default.
• W2037535664 creator A5028121388 @default.
• W2037535664 creator A5030018641 @default.
• W2037535664 creator A5037989560 @default.
• W2037535664 creator A5042973046 @default.
• W2037535664 creator A5046898426 @default.
• W2037535664 creator A5048837224 @default.
• W2037535664 creator A5061671556 @default.
• W2037535664 date "2015-05-01" @default.
• W2037535664 modified "2023-10-17" @default.
• W2037535664 title "Pharmacological activation of PPAR gamma ameliorates vascular endothelial insulin resistance via a non-canonical PPAR gamma-dependent nuclear factor-kappa B trans-repression pathway" @default.
• W2037535664 cites W1637651838 @default.
• W2037535664 cites W1966116864 @default.
• W2037535664 cites W1973341261 @default.
• W2037535664 cites W1978182359 @default.
• W2037535664 cites W1982277072 @default.
• W2037535664 cites W1982795519 @default.
• W2037535664 cites W1983832091 @default.
• W2037535664 cites W1989837170 @default.
• W2037535664 cites W1990837317 @default.
• W2037535664 cites W1997155097 @default.
• W2037535664 cites W2000522359 @default.
• W2037535664 cites W2003181992 @default.
• W2037535664 cites W2010390458 @default.
• W2037535664 cites W2020538038 @default.
• W2037535664 cites W2024761791 @default.
• W2037535664 cites W2039762060 @default.
• W2037535664 cites W2040972158 @default.
• W2037535664 cites W2044064996 @default.
• W2037535664 cites W2053789450 @default.
• W2037535664 cites W2054277796 @default.
• W2037535664 cites W2054506478 @default.
• W2037535664 cites W2056086815 @default.
• W2037535664 cites W2067806335 @default.
• W2037535664 cites W2083855314 @default.
• W2037535664 cites W2092884137 @default.
• W2037535664 cites W2098517576 @default.
• W2037535664 cites W2098525176 @default.
• W2037535664 cites W2110292220 @default.
• W2037535664 cites W2126412451 @default.
• W2037535664 cites W2128921112 @default.
• W2037535664 cites W2137725928 @default.
• W2037535664 cites W2144650199 @default.
• W2037535664 cites W2153497129 @default.
• W2037535664 cites W2154808210 @default.
• W2037535664 cites W2162078466 @default.
• W2037535664 cites W2164907741 @default.
• W2037535664 cites W2166961959 @default.
• W2037535664 cites W2171472351 @default.
• W2037535664 cites W2171646682 @default.
• W2037535664 cites W2172692903 @default.
• W2037535664 cites W2530180601 @default.
• W2037535664 doi "https://doi.org/10.1016/j.ejphar.2015.02.004" @default.
• W2037535664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25687252" @default.
• W2037535664 hasPublicationYear "2015" @default.
• W2037535664 type Work @default.
• W2037535664 sameAs 2037535664 @default.
• W2037535664 citedByCount "23" @default.
• W2037535664 countsByYear W20375356642016 @default.
• W2037535664 countsByYear W20375356642017 @default.
• W2037535664 countsByYear W20375356642018 @default.
• W2037535664 countsByYear W20375356642019 @default.
• W2037535664 countsByYear W20375356642020 @default.
• W2037535664 countsByYear W20375356642021 @default.
• W2037535664 countsByYear W20375356642022 @default.
• W2037535664 countsByYear W20375356642023 @default.
• W2037535664 crossrefType "journal-article" @default.
• W2037535664 hasAuthorship W2037535664A5007669734 @default.
• W2037535664 hasAuthorship W2037535664A5009476732 @default.
• W2037535664 hasAuthorship W2037535664A5012663740 @default.
• W2037535664 hasAuthorship W2037535664A5012949518 @default.
• W2037535664 hasAuthorship W2037535664A5014206663 @default.
• W2037535664 hasAuthorship W2037535664A5025565431 @default.
• W2037535664 hasAuthorship W2037535664A5028121388 @default.
• W2037535664 hasAuthorship W2037535664A5030018641 @default.
• W2037535664 hasAuthorship W2037535664A5037989560 @default.
• W2037535664 hasAuthorship W2037535664A5042973046 @default.
• W2037535664 hasAuthorship W2037535664A5046898426 @default.
• W2037535664 hasAuthorship W2037535664A5048837224 @default.
• W2037535664 hasAuthorship W2037535664A5061671556 @default.
• W2037535664 hasConcept C112446052 @default.
• W2037535664 hasConcept C123012128 @default.
• W2037535664 hasConcept C126322002 @default.
• W2037535664 hasConcept C134018914 @default.
• W2037535664 hasConcept C16224149 @default.
• W2037535664 hasConcept C170493617 @default.
• W2037535664 hasConcept C185592680 @default.
• W2037535664 hasConcept C187345961 @default.
• W2037535664 hasConcept C202751555 @default.
• W2037535664 hasConcept C2777391703 @default.
• W2037535664 hasConcept C2779306644 @default.

• next