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- W2037545901 abstract "Four water-soluble Ucon® fluids (butoxypolyoxyethylene polyoxypropylene glycols, 50-HB-260 and 50-HB-5100, I and II; polyoxyethylene polyoxypropylene glycols, 25-H-2005 and 75-H-1400, III and IV) were studied. The acute oral toxicities to rodents ranged from moderate to low as molecular weight increased. In the rat diet at 0.5 g/kg/day and the dog matching diet of 1.67%, I, II, and IV were without effect; III reduced growth of female rats and resulted in microscopic lesions of the dog intestinal wall muscle, but 0.1 g/kg/day and 0.33%, respectively, had no effect. The results of excretion studies with labeled samples did not distinguish between incomplete absorption from the digestive tract and high absorption followed by substantial excretion in the bile. Only 50-HB-260 resulted in appreciable respiratory carbon dioxide, originating from its butoxy and propoxy moieties." @default.
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- W2037545901 date "1970-05-01" @default.
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- W2037545901 title "Oral toxicity and excretion of four commercial polyoxyalkylene glycol compounds" @default.
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- W2037545901 doi "https://doi.org/10.1016/0041-008x(70)90072-4" @default.
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