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• W2037551004 abstract "The calcium-dependent protease calpain2 is involved in macrophages apoptosis. Brucella infection-induced up-regulation of intracellular calcium level is an essential factor for the intracellular survival of Brucella within macrophages. Here, we hypothesize that calcium-dependent E3 ubiquitin ligase Nedd4 ubiquitinates calpain2 and inhibits Brucella infection-induced macrophage apoptosis via degradation of calpain2.Our results reveal that Brucella infection induces increases in Nedd4 activity in an intracellular calcium dependent manner. Furthermore, Brucella infection-induced degradation of calpain2 is mediated by Nedd4 ubiquitination of calpain2. Brucella infection-induced calpain2 degradation inhibited macrophages apoptosis. Treatment of Brucella infected macrophages with calcium chelator BAPTA or Nedd4 knock-down decreased Nedd4 activity, prevented calpain2 degradation, and resulted in macrophages apoptosis." @default.
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• W2037551004 date "2014-11-01" @default.
• W2037551004 modified "2023-09-30" @default.
• W2037551004 title "Brucella infection inhibits macrophages apoptosis via Nedd4-dependent degradation of calpain2" @default.
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• W2037551004 doi "https://doi.org/10.1016/j.vetmic.2014.08.033" @default.
• W2037551004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25258171" @default.
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