FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037552018> ?p ?o ?g. }

• W2037552018 endingPage "1929" @default.
• W2037552018 startingPage "1918" @default.
• W2037552018 abstract "Plasma levels of endothelin-1 (ET-1) are increased in patients and animals with severe congestive heart failure (CHF). It remains unknown, however, whether ET-1 plays a direct and contributory role in the progression of CHF. Accordingly, the present project tested the hypothesis that chronic blockade of the ETA receptor would have direct and beneficial effects on left ventricular (LV) and myocyte function in a model of CHF.Global LV and isolated myocyte function were examined in rabbits in the following groups (12 per group): chronic rapid ventricular pacing (RVP; 400 bpm, 3 weeks), RVP and concomitant administration of the selective ETA receptor antagonist (PD 156707 24 mg/d), and sham controls. LV fractional shortening decreased after RVP (17 +/- 5 versus 42 +/- 3%) and end-diastolic dimension increased (2.36 +/- 0.44 versus 1.24 +/- 0.18 cm) compared with controls (P < .05). With RVP plus ETA blockade, LV fractional shortening was increased (33 +/- 6%) and end-diastolic dimension decreased (2.02 +/- 0.30 cm) compared with RVP-only values (P < .05). Plasma norepinephrine and endothelin increased twofold in the RVP group. In the RVP plus ETA blockade group, plasma endothelin increased threefold compared with RVP values. Isolated myocyte shortening velocity declined after RVP (42 +/- 13 versus 72 +/- 10 microns/s, P < .05) compared with controls but was normalized with RVP plus ETA blockade (77 +/- 16 microns/s). Myocyte inotropic response to extracellular Ca2+, beta-receptor stimulation, and ET-1 was reduced in the RVP group and returned to control levels with RVP and concomitant ETA receptor blockade.The results from this study suggest that chronically elevated ET-1 levels and subsequent activation of the ETA receptor play a direct and contributory role in the progression of the CHF process. Thus, specific ETA receptor blockade may provide a new and useful therapeutic modality in the setting of CHF." @default.
• W2037552018 created "2016-06-24" @default.
• W2037552018 creator A5011727156 @default.
• W2037552018 creator A5017632021 @default.
• W2037552018 creator A5036466656 @default.
• W2037552018 creator A5041498326 @default.
• W2037552018 creator A5060817248 @default.
• W2037552018 creator A5083914588 @default.
• W2037552018 date "1997-04-01" @default.
• W2037552018 modified "2023-09-23" @default.
• W2037552018 title "Concomitant Endothelin Receptor Subtype-A Blockade During the Progression of Pacing-Induced Congestive Heart Failure in Rabbits" @default.
• W2037552018 cites W1963693887 @default.
• W2037552018 cites W1973758148 @default.
• W2037552018 cites W1977446631 @default.
• W2037552018 cites W1979604318 @default.
• W2037552018 cites W1982661170 @default.
• W2037552018 cites W1987811756 @default.
• W2037552018 cites W1988345896 @default.
• W2037552018 cites W2003541670 @default.
• W2037552018 cites W2010800692 @default.
• W2037552018 cites W2012701873 @default.
• W2037552018 cites W2020276498 @default.
• W2037552018 cites W2020724779 @default.
• W2037552018 cites W2031609571 @default.
• W2037552018 cites W2034587587 @default.
• W2037552018 cites W2045732728 @default.
• W2037552018 cites W2046102701 @default.
• W2037552018 cites W2048830043 @default.
• W2037552018 cites W2050356686 @default.
• W2037552018 cites W2060182387 @default.
• W2037552018 cites W2067755114 @default.
• W2037552018 cites W2069259882 @default.
• W2037552018 cites W2092352619 @default.
• W2037552018 cites W2095647887 @default.
• W2037552018 cites W2097149135 @default.
• W2037552018 cites W2131083572 @default.
• W2037552018 cites W2162804111 @default.
• W2037552018 doi "https://doi.org/10.1161/01.cir.95.7.1918" @default.
• W2037552018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9107181" @default.
• W2037552018 hasPublicationYear "1997" @default.
• W2037552018 type Work @default.
• W2037552018 sameAs 2037552018 @default.
• W2037552018 citedByCount "111" @default.
• W2037552018 countsByYear W20375520182012 @default.
• W2037552018 countsByYear W20375520182013 @default.
• W2037552018 countsByYear W20375520182015 @default.
• W2037552018 countsByYear W20375520182016 @default.
• W2037552018 countsByYear W20375520182019 @default.
• W2037552018 countsByYear W20375520182020 @default.
• W2037552018 countsByYear W20375520182021 @default.
• W2037552018 crossrefType "journal-article" @default.
• W2037552018 hasAuthorship W2037552018A5011727156 @default.
• W2037552018 hasAuthorship W2037552018A5017632021 @default.
• W2037552018 hasAuthorship W2037552018A5036466656 @default.
• W2037552018 hasAuthorship W2037552018A5041498326 @default.
• W2037552018 hasAuthorship W2037552018A5060817248 @default.
• W2037552018 hasAuthorship W2037552018A5083914588 @default.
• W2037552018 hasConcept C126322002 @default.
• W2037552018 hasConcept C134018914 @default.
• W2037552018 hasConcept C144980905 @default.
• W2037552018 hasConcept C149601957 @default.
• W2037552018 hasConcept C155710745 @default.
• W2037552018 hasConcept C164705383 @default.
• W2037552018 hasConcept C170493617 @default.
• W2037552018 hasConcept C2778198053 @default.
• W2037552018 hasConcept C2778468042 @default.
• W2037552018 hasConcept C2779384505 @default.
• W2037552018 hasConcept C71924100 @default.
• W2037552018 hasConceptScore W2037552018C126322002 @default.
• W2037552018 hasConceptScore W2037552018C134018914 @default.
• W2037552018 hasConceptScore W2037552018C144980905 @default.
• W2037552018 hasConceptScore W2037552018C149601957 @default.
• W2037552018 hasConceptScore W2037552018C155710745 @default.
• W2037552018 hasConceptScore W2037552018C164705383 @default.
• W2037552018 hasConceptScore W2037552018C170493617 @default.
• W2037552018 hasConceptScore W2037552018C2778198053 @default.
• W2037552018 hasConceptScore W2037552018C2778468042 @default.
• W2037552018 hasConceptScore W2037552018C2779384505 @default.
• W2037552018 hasConceptScore W2037552018C71924100 @default.
• W2037552018 hasIssue "7" @default.
• W2037552018 hasLocation W20375520181 @default.
• W2037552018 hasLocation W20375520182 @default.
• W2037552018 hasOpenAccess W2037552018 @default.
• W2037552018 hasPrimaryLocation W20375520181 @default.
• W2037552018 hasRelatedWork W1983371938 @default.
• W2037552018 hasRelatedWork W2013484267 @default.
• W2037552018 hasRelatedWork W2032437128 @default.
• W2037552018 hasRelatedWork W2095084418 @default.
• W2037552018 hasRelatedWork W2137737323 @default.
• W2037552018 hasRelatedWork W2143238233 @default.
• W2037552018 hasRelatedWork W2160355439 @default.
• W2037552018 hasRelatedWork W2377343248 @default.
• W2037552018 hasRelatedWork W4245472597 @default.
• W2037552018 hasRelatedWork W3112242473 @default.
• W2037552018 hasVolume "95" @default.
• W2037552018 isParatext "false" @default.
• W2037552018 isRetracted "false" @default.
• W2037552018 magId "2037552018" @default.

• next