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- W2037560205 abstract "Parametric survivorship analyses of clinical trials commonly involves the assumption of a hazard function constant with time. When the empirical curve obviously levels off, one can modify the hazard function model by use of a Gompertz or Weibull distribution with hazard decreasing over time. Some cancer treatments are thought to cure some patients within a short time of initiation. Then, instead of all patients having the same hazard, decreasing over time, a biologically more appropriate model assumes that an unknown proportion (1 - pi) have constant high risk whereas the remaining proportion (pi) have essentially no risk. This paper discusses the maximum likelihood estimation of pi and the power curves of the likelihood ratio test. Monte Carlo studies provide results for a variety of simulated trials; empirical data illustrate the methods." @default.
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- W2037560205 date "1984-04-01" @default.
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- W2037560205 title "Survivorship analysis when cure is a possibility: A monte carlo study" @default.
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- W2037560205 doi "https://doi.org/10.1002/sim.4780030208" @default.
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