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- W2037570904 abstract "The presence of serum from chronic chagasic patients or rabbits immunized with killed epimastigote forms of Trypanosoma cruzi inhibited infection of rat heart myoblasts by insect-vector (Triatoma infestans)-derived, metacyclic forms of Trypanosoma cruzi. The effect was produced even after diluting the chagasic serum to non-agglutinating levels and was evidenced by marked reductions in both the percentage of infected myoblasts and the number of parasites per 100 cells. Human IgG or IgM purified from chronic chagasic serum and serum from rabbits immunized with killed T. cruzi epimastigotes also reduced both parameters. While previous work has shown that immunological destruction of invasive forms of T. cruzi may underlie the protective effects of the humoral immune response against this parasite, the present in vitro results suggest that specific anti- T. cruzi antibodies could also contribute to protection via inhibition of host cell infection by the vectortransmissible form of the parasite." @default.
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- W2037570904 date "1987-02-01" @default.
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- W2037570904 title "Inhibition of mammalian host cell infection by insect-derived, metacyclic forms of Trypanosoma cruzi in the presence of human or rabbit anti- T. Cruzi antibodies" @default.
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- W2037570904 doi "https://doi.org/10.1016/0020-7519(87)90067-1" @default.
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