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- W2037571406 abstract "Introduction Skeletal muscle impairment is a well recognised complication of COPD, predicting mortality in severe disease. 1 Evidence from animal models, genetic studies and observational cohorts suggest a role for the renin-angiotensin system in control of muscle phenotype. 2 We hypothesised that angiotensin-converting enzyme (ACE) inhibition would have a beneficial effect on quadriceps function in patients with COPD. Methods A single-centre, double-blind randomised controlled parallel-group trial investigating the effect of fosinopril versus placebo on quadriceps muscle dysfunction in COPD patients with quadriceps weakness. Muscle weakness was defined as a quadriceps maximum voluntary contraction (QMVC) less than 120% of the body mass index.1 Measurements The primary outcome was change in non-volitional quadriceps endurance at 3 months, measured using repetitive magnetic stimulation. QMVC, mid-thigh CT cross-sectional area (MT CSA ), incremental shuttle walk distance (ISWD) and serum inflammatory markers were secondary outcomes. Results 80 patients were enrolled (mean(SD), 65(8) years, FEV1 43(21)% predicted, 53% male). 67 patients (31 fosinopril and 36 placebo) completed the trial, with the treatment group demonstrating a significant reduction in systolic blood pressure (Δ-10.5mmHg, 95%CI –19.9 to –1.1, p=0.03) and serum ACE activity (Δ-20.4units/L, 95%CI –31.0 to –9.8, p Conclusion This randomised controlled trial found that ACE-inhibition did not improve quadriceps function in a COPD population with quadriceps weakness. Study funded by the Medical Research Council. Trial registration: NCT01014338. Swallow EB, et al . Thorax 2007; 62:115–20. Shrikrishna D, et al . Clin Sci 2012; 123:487–98." @default.
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- W2037571406 date "2012-11-19" @default.
- W2037571406 modified "2023-10-15" @default.
- W2037571406 title "S48 The Effect of Angiotensin-Converting Enzyme Inhibition on Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease: A Randomised Controlled Trial" @default.
- W2037571406 doi "https://doi.org/10.1136/thoraxjnl-2012-202678.054" @default.
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