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- W2037576801 abstract "The effect of 3,4-dihydroxyphenylalanine (L-dopa) treatment of the ability of intact human cells to metabolize substrates for mitochondrial oxidative phosphorylation was studied in embryonic fibroblasts. Treatment with L-dopa (100–400 μM) for 48 h significantly reduced the oxidation of pyruvate but had no effect on succinate oxidation. The effect was dose-dependent and was still present 2 days after removal of L-dopa. Ascorbic acid (200 μM) protected the cells from the effects of L-dopa; ascorbate alone enhanced pyruvate but not succinate oxidation." @default.
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- W2037576801 date "1994-09-01" @default.
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- W2037576801 title "Impaired oxidation of pyruvate in human embryonic fibroblasts after exposure to L-dopa" @default.
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- W2037576801 doi "https://doi.org/10.1016/0014-2999(94)90536-3" @default.
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