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• W2037584248 abstract "In the present study we investigated, the effect of third ventricle injections of IL-1β on water intake, in rats, induced by three different physiological stimuli: dehydration induced by water deprivation, hypernatremia associated with hyperosmolarity induced by intragastric salt load, and hypovolemia produced by subcutaneous polytethyleneglycol administration. Central administration of IL-1β at the doses of 4 and 8 ng reduced water intake in all three conditions studied. Third ventricle injections of IL-1β (8 ng) were unable to diminish water intake in the groups of rats pretreated with central injections of the non-selective opioid antagonist naloxone (10 μg) in the three different conditions studied. Furthermore, the central administration of IL-1β was neither able to modify the intake of a 0.1% saccharin solution when the animals were submitted to a “dessert test” nor to induce any significant locomotor deficit in the open-field test. These results suggest that the central activation of interleukin-1 receptors by IL-1β is able to impair the thirst-inducing mechanisms triggered by the physiological stimuli represented by dehydration, hyperosmolarity and hypovolemia. These results lead us to conclude that the antidipsogenic effects observed following central administration of IL-1β require the functional integrity of the brain opiatergic system." @default.
• W2037584248 created "2016-06-24" @default.
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• W2037584248 date "2006-04-01" @default.
• W2037584248 modified "2023-09-27" @default.
• W2037584248 title "Inhibition of water intake by the central administration of IL-1β in rats: Role of the central opioid system" @default.
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• W2037584248 doi "https://doi.org/10.1016/j.npep.2005.11.001" @default.
• W2037584248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16375968" @default.
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