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- W2037584349 abstract "The mechanisms of action of estradiol in the nervous system involve nuclear-initiated steroid signaling and membrane-initiated steroid signaling. Estrogen receptors (ERs) are involved in both mechanisms. ERα interacts with the signaling of IGF-1 receptor in neural cells: ERα transcriptional activity is regulated by IGF-1 receptor signaling and estradiol regulates IGF-1 receptor signaling. The interaction between ERα and the IGF-1 receptor in the brain may occur at the plasma membrane of neurons and glial cells. Caveolin-1 may provide the scaffolding for the interaction of different membrane-associated molecules, including voltage-dependent anion channel, ERα and IGF-I receptor." @default.
- W2037584349 created "2016-06-24" @default.
- W2037584349 creator A5000909627 @default.
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- W2037584349 creator A5068357431 @default.
- W2037584349 date "2009-03-01" @default.
- W2037584349 modified "2023-10-17" @default.
- W2037584349 title "Role of estrogen receptor α in membrane-initiated signaling in neural cells: Interaction with IGF-1 receptor" @default.
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