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• W2037591506 endingPage "1309" @default.
• W2037591506 startingPage "1299" @default.
• W2037591506 abstract "Abstract Agonist activation of central 5‐HT 2A receptors results in diverse effects, such as hallucinations and changes of consciousness. Recent findings indicate that activation of the 5‐HT 2A receptor also leads to interesting physiological responses, possibly holding therapeutic value. Selective agonists are needed to study the full therapeutic potential of this receptor. 5‐HT 2A ligands with agonist profiles are primarily derived from phenylalkylamines, indolealkylamines, and certain piperazines. Of these, phenylalkylamines, most notably substituted phenylisopropylamines, are considered the most selective agonists for 5‐HT 2 receptors. This review summarizes the structure–activity relationships (SAR) of phenylalkylamines as agonist ligands for 5‐HT 2A receptors. Selectivity is a central theme, as is selectivity for the 5‐HT 2A receptor and for its specific signaling pathways. SAR data from receptor affinity studies, functional assays, behavioral drug discrimination as well as human studies are discussed." @default.
• W2037591506 created "2016-06-24" @default.
• W2037591506 creator A5049413527 @default.
• W2037591506 creator A5056598518 @default.
• W2037591506 creator A5085773260 @default.
• W2037591506 date "2008-09-05" @default.
• W2037591506 modified "2023-10-12" @default.
• W2037591506 title "Structure-Activity Relationships of Phenylalkylamines as Agonist Ligands for 5-HT_2AReceptors" @default.
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