FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037593288> ?p ?o ?g. }

• W2037593288 endingPage "463" @default.
• W2037593288 startingPage "437" @default.
• W2037593288 abstract "The present study reports on the microglial populations present in 34 regions of the human infant brain (1–11 months), and whether developmental parameters or extrinsic factors such as cigarette smoke exposure, prone sleeping and an upper respiratory tract infection (URTI) influence their expression. Further, we compare microglia populations amongst three sudden unexpected death in infancy (SUDI) sub-groups: explained SUDI (eSUDI, n ​= ​7), sudden infant death syndrome (SIDS) I (n ​= ​8) and SIDS II (n ​= ​13). Ionised calcium binding adaptor molecule-1 (Iba1) was used to determine the morphology and area covered by microglia in a given brain region. Activation was explored using cluster-of-differentiation factor 68 (CD68) and human leukocyte antigen-DP,DQ,DR (HLA). We found regional heterogeneity in the area covered and activation status of microglia across the infant brain. The hippocampus, basal ganglia, white matter and dentate nucleus of the cerebellum showed larger areas of Iba1, while the brainstem had the smallest. Microglia in regions of the basal ganglia and cortex demonstrated positive correlations with infant developmental parameters, while in nuclei of the rostral medulla, negative correlations between microglia parameters were seen. URTI and cigarette smoke exposure were associated with a reduced microglial area in regions of the hippocampus and cortex (parietal and occipital), respectively. In the context of SIDS, a reduced microglial area was seen in SIDS II and fewer SIDS I infants demonstrated activated phenotypes in the hippocampus. Overall, we identify the distribution of microglia in the infant brain to be heterogenous, and influenced by intrinsic and extrinsic factors, and that the SIDS I group is a useful control group for future research into other infant CNS pathologies." @default.
• W2037593288 created "2016-06-24" @default.
• W2037593288 creator A5052715673 @default.
• W2037593288 creator A5069915039 @default.
• W2037593288 date "1991-01-01" @default.
• W2037593288 modified "2023-10-18" @default.
• W2037593288 title "Quantitatives studies on the mammalian cerebellum" @default.
• W2037593288 cites W112501236 @default.
• W2037593288 cites W143324445 @default.
• W2037593288 cites W1485458686 @default.
• W2037593288 cites W1550911063 @default.
• W2037593288 cites W1561393469 @default.
• W2037593288 cites W1582681335 @default.
• W2037593288 cites W1968401611 @default.
• W2037593288 cites W1977311786 @default.
• W2037593288 cites W1980944165 @default.
• W2037593288 cites W1985696256 @default.
• W2037593288 cites W1989108824 @default.
• W2037593288 cites W1991069673 @default.
• W2037593288 cites W1993407970 @default.
• W2037593288 cites W1993910523 @default.
• W2037593288 cites W1998789347 @default.
• W2037593288 cites W2000305574 @default.
• W2037593288 cites W2002665694 @default.
• W2037593288 cites W2005628671 @default.
• W2037593288 cites W2013275286 @default.
• W2037593288 cites W2013874304 @default.
• W2037593288 cites W2026511288 @default.
• W2037593288 cites W2029101208 @default.
• W2037593288 cites W2029804483 @default.
• W2037593288 cites W2035171821 @default.
• W2037593288 cites W2038582816 @default.
• W2037593288 cites W2042744314 @default.
• W2037593288 cites W2044175751 @default.
• W2037593288 cites W2049931012 @default.
• W2037593288 cites W2051736447 @default.
• W2037593288 cites W2054525629 @default.
• W2037593288 cites W2056177071 @default.
• W2037593288 cites W2056435002 @default.
• W2037593288 cites W2058860968 @default.
• W2037593288 cites W2059728534 @default.
• W2037593288 cites W2059984249 @default.
• W2037593288 cites W2063098888 @default.
• W2037593288 cites W2064111706 @default.
• W2037593288 cites W2064679863 @default.
• W2037593288 cites W2069999958 @default.
• W2037593288 cites W2075572784 @default.
• W2037593288 cites W2075770900 @default.
• W2037593288 cites W2076376539 @default.
• W2037593288 cites W2076824670 @default.
• W2037593288 cites W2084694470 @default.
• W2037593288 cites W2085009615 @default.
• W2037593288 cites W2085047375 @default.
• W2037593288 cites W2086237372 @default.
• W2037593288 cites W2088535609 @default.
• W2037593288 cites W2094276452 @default.
• W2037593288 cites W2097255899 @default.
• W2037593288 cites W2105382539 @default.
• W2037593288 cites W2106875648 @default.
• W2037593288 cites W2127911529 @default.
• W2037593288 cites W2129433818 @default.
• W2037593288 cites W2140989716 @default.
• W2037593288 cites W2152209402 @default.
• W2037593288 cites W2160193852 @default.
• W2037593288 cites W2409385147 @default.
• W2037593288 cites W2413436444 @default.
• W2037593288 cites W2418460684 @default.
• W2037593288 cites W244979854 @default.
• W2037593288 cites W2473867947 @default.
• W2037593288 cites W2479391679 @default.
• W2037593288 cites W2497308867 @default.
• W2037593288 cites W2500961177 @default.
• W2037593288 cites W278926048 @default.
• W2037593288 cites W2798409858 @default.
• W2037593288 cites W2986312945 @default.
• W2037593288 cites W2996479446 @default.
• W2037593288 cites W3114713417 @default.
• W2037593288 cites W571293582 @default.
• W2037593288 cites W63191422 @default.
• W2037593288 doi "https://doi.org/10.1016/0301-0082(91)90012-p" @default.
• W2037593288 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1947173" @default.
• W2037593288 hasPublicationYear "1991" @default.
• W2037593288 type Work @default.
• W2037593288 sameAs 2037593288 @default.
• W2037593288 citedByCount "183" @default.
• W2037593288 countsByYear W20375932882012 @default.
• W2037593288 countsByYear W20375932882013 @default.
• W2037593288 countsByYear W20375932882014 @default.
• W2037593288 countsByYear W20375932882015 @default.
• W2037593288 countsByYear W20375932882016 @default.
• W2037593288 countsByYear W20375932882017 @default.
• W2037593288 countsByYear W20375932882018 @default.
• W2037593288 countsByYear W20375932882019 @default.
• W2037593288 countsByYear W20375932882020 @default.
• W2037593288 countsByYear W20375932882021 @default.
• W2037593288 countsByYear W20375932882022 @default.
• W2037593288 countsByYear W20375932882023 @default.
• W2037593288 crossrefType "journal-article" @default.

• next