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• W2037593864 endingPage "1085" @default.
• W2037593864 startingPage "1077" @default.
• W2037593864 abstract "ABSTRACT Surfactant proteins A and D (SP-A and -D) play a role in many acute bacterial, viral, and fungal infections and in acute allergic responses. In vitro , human SPs bind Mycobacterium tuberculosis and alter human and rat macrophage-mediated functions. Here we report the roles of SP-A and SP-D in M. tuberculosis infection following aerosol challenge of SP-A-, SP-D-, and SP-A/-D-deficient mice. These studies surprisingly identified no gross defects in uptake or immune control of M. tuberculosis in SP-A-, SP-D-, and SP-A/-D-deficient mice. While both SP-A- and SP-D-deficient mice exhibited evidence of immunopathologic defects, the CD11b high CD11c high dendritic cell populations and the gamma interferon (IFN-γ)-dependent CD4 + T cell response to M. tuberculosis were unaltered in all genotypes tested. Together, these data indicate that SP-A and SP-D are dispensable for immune control of M. tuberculosis in a low-dose, aerosol challenge, murine model of tuberculosis (TB)." @default.
• W2037593864 created "2016-06-24" @default.
• W2037593864 creator A5009066976 @default.
• W2037593864 creator A5040943483 @default.
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• W2037593864 date "2011-03-01" @default.
• W2037593864 modified "2023-10-10" @default.
• W2037593864 title "Dispensability of Surfactant Proteins A and D in Immune Control of<i>Mycobacterium tuberculosis</i>Infection following Aerosol Challenge of Mice" @default.
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• W2037593864 doi "https://doi.org/10.1128/iai.00286-10" @default.
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• W2037593864 hasPublicationYear "2011" @default.
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