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- W2037596229 abstract "The hippocampal pyramidal cells receive a cholinergic input from septum. They also project back to the septum where they contribute to the feedback regulation of septal cholinergic neurons. This feedback pathway was studied and an attempt was made to identify the transmitter that is operative and to define its role in the generation of neuronal activity in septal nuclei. Measurements of the glutamate content and uptake in septum after lesions of the hippocampal fimbria show changes that would be expected if this pathway were glutamatergic. These findings are supported by studies in which hippocampal pyramidal cells are lesioned with kainic acid injections. While this chemical lesion of the hippocampus disrupts the function of the glutamatergic feedback to the septum, it fails to change the turnover rate of acetylcholine in the hippocampus. These data support the hypothesis that septal activity is dependent upon a septal pacemaker which is not directly linked with the hippocampal feedback input." @default.
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- W2037596229 date "1979-06-01" @default.
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- W2037596229 title "The turnover rate of ach in the hippocampus after lesion of hippocampal pyramidal cells with kainic acid" @default.
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- W2037596229 doi "https://doi.org/10.1016/0028-3908(79)90094-7" @default.
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