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- W2037597323 abstract "Catechins containing galloyl moieties are important natural antioxidant compounds. In this paper, we review the multiple mechanisms whereby catechins containing a galloyl moiety can target key proteins to inhibit sexual transmission of HIV-1, as well as HIV-1 fusion, HIV-1 reverse transcriptase, HIV-1 integrase and HIV-1 protease. Furthermore, catechins with a galloyl moiety can mediate host cell factors such as nitric oxide synthase, nuclear factor-κB and casein kinase II to inhibit HIV-1 infection. The most significant inhibitory effect is blocking gp120 binding to isolated human CD4+ T cells. The multiple mechanisms underlying the anti-HIV activity of galloyl-containing catechins predict that these catechins could be used as alternative therapies in the treatment of HIV infection." @default.
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- W2037597323 date "2012-06-01" @default.
- W2037597323 modified "2023-09-25" @default.
- W2037597323 title "Catechins containing a galloyl moiety as potential anti-HIV-1 compounds" @default.
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- W2037597323 doi "https://doi.org/10.1016/j.drudis.2012.02.015" @default.
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