FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037602803> ?p ?o ?g. }

• W2037602803 endingPage "264" @default.
• W2037602803 startingPage "258" @default.
• W2037602803 abstract "Some chronic myeloid leukemia (CML) patients do not respond to imatinib, whereas others lose an initial response. To identify potential imatinib failures, we investigated the expression of imatinib uptake transporter (human organic cation transporter 1; hOCT1) and efflux transporters (ATP-binding cassette transporters ABCB1, ABCG2, and ABCC1) using real-time quantitative reverse transcription-polymerase chain reaction in 70 CML patients. Patients with high pretreatment hOCT1 expression had superior complete cytogenetic response (CCR) rates (P=0.008), progression-free and overall survival (P=0.01 and 0.004). Pretreatment ABCB1, ABCG2, and ABCC1 levels did not correlate with treatment outcome. Regression analysis demonstrated that pretreatment hOCT1 expression was the most powerful predictor of CCR achievement at 6 months (P=0.002). Imatinib uptake into a CML cell line with high hOCT1 expression was greater than into those with modest or low expression (P=0.002). The expression of hOCT1, but not efflux transporters, is important in determining the clinical response to imatinib." @default.
• W2037602803 created "2016-06-24" @default.
• W2037602803 creator A5006847944 @default.
• W2037602803 creator A5013531522 @default.
• W2037602803 creator A5072801492 @default.
• W2037602803 creator A5074872662 @default.
• W2037602803 creator A5084825146 @default.
• W2037602803 creator A5091359239 @default.
• W2037602803 date "2007-06-13" @default.
• W2037602803 modified "2023-09-26" @default.
• W2037602803 title "Expression of the Uptake Drug Transporter hOCT1 is an Important Clinical Determinant of the Response to Imatinib in Chronic Myeloid Leukemia" @default.
• W2037602803 cites W1967920366 @default.
• W2037602803 cites W1968071128 @default.
• W2037602803 cites W1975595356 @default.
• W2037602803 cites W1976818967 @default.
• W2037602803 cites W1984246155 @default.
• W2037602803 cites W1994400524 @default.
• W2037602803 cites W2002777245 @default.
• W2037602803 cites W2003596377 @default.
• W2037602803 cites W2009323095 @default.
• W2037602803 cites W2011474502 @default.
• W2037602803 cites W2020626823 @default.
• W2037602803 cites W2025950197 @default.
• W2037602803 cites W2026389791 @default.
• W2037602803 cites W2028959752 @default.
• W2037602803 cites W2035090455 @default.
• W2037602803 cites W2035910722 @default.
• W2037602803 cites W2049426761 @default.
• W2037602803 cites W2060996760 @default.
• W2037602803 cites W2061860992 @default.
• W2037602803 cites W2065100318 @default.
• W2037602803 cites W2070067474 @default.
• W2037602803 cites W2082469361 @default.
• W2037602803 cites W2083698338 @default.
• W2037602803 cites W2098785293 @default.
• W2037602803 cites W2101390452 @default.
• W2037602803 cites W2106114964 @default.
• W2037602803 cites W2107268345 @default.
• W2037602803 cites W2108203538 @default.
• W2037602803 cites W2117569938 @default.
• W2037602803 cites W2122367401 @default.
• W2037602803 cites W2126376257 @default.
• W2037602803 cites W2127444056 @default.
• W2037602803 cites W2129342281 @default.
• W2037602803 cites W2129382787 @default.
• W2037602803 cites W2143489360 @default.
• W2037602803 cites W2147537382 @default.
• W2037602803 cites W2153795107 @default.
• W2037602803 cites W2167829945 @default.
• W2037602803 cites W2170326611 @default.
• W2037602803 cites W2188149910 @default.
• W2037602803 doi "https://doi.org/10.1038/sj.clpt.6100268" @default.
• W2037602803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17568400" @default.
• W2037602803 hasPublicationYear "2007" @default.
• W2037602803 type Work @default.
• W2037602803 sameAs 2037602803 @default.
• W2037602803 citedByCount "251" @default.
• W2037602803 countsByYear W20376028032012 @default.
• W2037602803 countsByYear W20376028032013 @default.
• W2037602803 countsByYear W20376028032014 @default.
• W2037602803 countsByYear W20376028032015 @default.
• W2037602803 countsByYear W20376028032016 @default.
• W2037602803 countsByYear W20376028032017 @default.
• W2037602803 countsByYear W20376028032018 @default.
• W2037602803 countsByYear W20376028032019 @default.
• W2037602803 countsByYear W20376028032020 @default.
• W2037602803 countsByYear W20376028032021 @default.
• W2037602803 countsByYear W20376028032022 @default.
• W2037602803 countsByYear W20376028032023 @default.
• W2037602803 crossrefType "journal-article" @default.
• W2037602803 hasAuthorship W2037602803A5006847944 @default.
• W2037602803 hasAuthorship W2037602803A5013531522 @default.
• W2037602803 hasAuthorship W2037602803A5072801492 @default.
• W2037602803 hasAuthorship W2037602803A5074872662 @default.
• W2037602803 hasAuthorship W2037602803A5084825146 @default.
• W2037602803 hasAuthorship W2037602803A5091359239 @default.
• W2037602803 hasConcept C104317684 @default.
• W2037602803 hasConcept C126322002 @default.
• W2037602803 hasConcept C143998085 @default.
• W2037602803 hasConcept C149011108 @default.
• W2037602803 hasConcept C189613389 @default.
• W2037602803 hasConcept C200082930 @default.
• W2037602803 hasConcept C2777583451 @default.
• W2037602803 hasConcept C2778729363 @default.
• W2037602803 hasConcept C3019892230 @default.
• W2037602803 hasConcept C44312359 @default.
• W2037602803 hasConcept C502942594 @default.
• W2037602803 hasConcept C512196 @default.
• W2037602803 hasConcept C54355233 @default.
• W2037602803 hasConcept C63443662 @default.
• W2037602803 hasConcept C71924100 @default.
• W2037602803 hasConcept C86803240 @default.
• W2037602803 hasConcept C98274493 @default.
• W2037602803 hasConceptScore W2037602803C104317684 @default.
• W2037602803 hasConceptScore W2037602803C126322002 @default.
• W2037602803 hasConceptScore W2037602803C143998085 @default.
• W2037602803 hasConceptScore W2037602803C149011108 @default.
• W2037602803 hasConceptScore W2037602803C189613389 @default.

• next