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- W2037604538 abstract "The transforming growth factors (TGF) type β1 and β2 are regulatory cytokines strongly affecting rat astrocyte immune functions. Both cytokines suppressed presentation of autoantigen by astrocytes: highly encephalotogenic T cells cocultured with TGF-β-treated astrocytes in the presence of myelin basic protein did not become activated to transfer experimental allergic encephalomyelitis, a central nervous system (CNS) autoimmune disease. Furthermore, TGF-β1 and -β2 antagonized hyperinduction of astrocyte major histocompatibility complex (MHC) class II antigen expression by interferon-γ and tumor necrosis factor-α. Thus, TGF-β might be a potential regulator of CNS inflammation." @default.
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- W2037604538 date "1990-04-01" @default.
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- W2037604538 title "Transforming growth factors type β1 and β2 suppress rat astrocyte autoantigen presentation and antagonize hyperinduction of class II major histocompatibility complex antigen expression by interferon-γ and tumor necrosis factor-α" @default.
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- W2037604538 doi "https://doi.org/10.1016/0165-5728(90)90134-9" @default.
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