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• W2037608269 abstract "Six new copper(II) complexes of thiosemicarbazone Schiff base with isatin moiety were synthesized. The interaction of these compounds with calf thymus (CT) DNA exhibited high intrinsic binding constant. CuL1 and CuL2 showed ability to cleave the DNA by oxidative pathway only, whereas CuL3 , CuL4 , CuL5 and CuL6 induced DNA cleavage via oxidative and hydrolytic pathway. The in vitro anti-proliferative study clearly establishes the anticancer potency of these complexes against (HCT 116). Six new Cu(II) complexes of thiosemicarbazone Schiff base with isatin moiety were synthesized through the reaction of Cu(II) with (Z)-2-(2-oxoindolin-3-ylidene)-N-phenylhydrazinecarbothioamide ( CuL1 ), (Z)-2-(5-methyl-2-oxoindolin-3-ylidene)-N-phenylhydrazinecarbothioamide ( CuL2 ), (Z)-2-(5-fluoro-2-oxoindolin-3-ylidene)-N-phenylhydrazinecarbothioamide ( CuL3 ), (Z)-N-methyl-2-(5-nitro-2-oxoindolin-3-ylidene)hydrazinecarbothioamide ( CuL4 ), (Z)-N-methyl-2-(5-methyl-2-oxoindolin-3-ylidene)hydrazinecarbothioamide ( CuL5 ), and (Z)-N-ethyl-2-(5-methyl-2-oxoindolin-3-ylidene)hydrazinecarbothioamide ( CuL6 ). The structures of the Schiff bases and their copper complexes were characterized based on the elemental analysis, and on the infrared, UV–Vis, 1 H and 13 C NMR and ESI-mass spectral data. The structures of the CuL2 and CuL3 complexes were further characterized by single-crystal X-ray diffraction. The interaction of these complexes with calf thymus (CT)-DNA exhibited high intrinsic binding constant ( K b = 1.6 × 10 5 –14.6 × 10 5 M −1 ), which reflected intercalative activity of these complexes toward CT-DNA. This result was also confirmed by the viscosity data. Electrophoresis studies revealed that the CuL1 and CuL2 complexes were able to cleave the DNA via oxidative pathway, whereas CuL3, CuL4, CuL5, and CuL6 induced DNA cleavage via oxidative and hydrolytic pathways. The in vitro anti-proliferative study establishes the anticancer potency of these compounds against the human colorectal carcinoma cell line." @default.
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• W2037608269 date "2014-05-01" @default.
• W2037608269 modified "2023-10-16" @default.
• W2037608269 title "Synthesis of copper(II) complexes of isatin thiosemicarbazone derivatives: In vitro anti-cancer, DNA binding, and cleavage activities" @default.
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• W2037608269 doi "https://doi.org/10.1016/j.poly.2014.02.025" @default.
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