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- W2037614125 abstract "► We have developed poly(N-vinyl caprolactam-co-acrylamidoglycolic acid) based nanogels for controlled release of an anticancer drugs. ► This system exhibited dual responsive nature, and accelerated drug release profile. ► The cumulative release data were analysed using an emperical equation to compute the diffusion coefficient; it suggest Fickian diffusion. A series of novel nanogels (NGs) with both pH and thermoresponsive properties were synthesised by free radical emulsion polymerisation of N-vinyl caprolactam (VCL) and acrylamidoglycolic acid (AGA). 5-Flurouracil, an anti cancer drug, was successfully loaded into these nanogels via equilibrium swelling method. The encapsulation efficiency of 5-FU was found up to 61%. Here we present the novel potential drug delivery system showing both pH and temperature release of 5-FU. Fourier transforms infrared spectroscopy (FTIR), and differential scanning calorimetric (DSC) examined the structure and morphology of the NGs. Transmission electron microscopy (TEM) indicates the diameter of the NGs to be about 50 nm. The size distribution of NGs was investigated using dynamic light scattering (DLS), the average diameter and polydispersity is 57 nm and 0.194. Interestingly, the in vitro release studies of 5-FU demonstrated the dual nature (pH and temperature) of NGs. The cumulative release data were analysed using an emperical equation to compute the diffusion exponent ( n ); whose values suggest Fickian diffusion." @default.
- W2037614125 created "2016-06-24" @default.
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- W2037614125 date "2013-02-01" @default.
- W2037614125 modified "2023-09-27" @default.
- W2037614125 title "Novel thermo/pH sensitive nanogels composed from poly(N-vinylcaprolactam) for controlled release of an anticancer drug" @default.
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- W2037614125 doi "https://doi.org/10.1016/j.colsurfb.2012.09.009" @default.
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