FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037617680> ?p ?o ?g. }

• W2037617680 endingPage "2094" @default.
• W2037617680 startingPage "2086" @default.
• W2037617680 abstract "The cortical cytoskeleton constitutes an important subcellular structure that determines cell shape and regulates cell migration as well as membrane traffic to and from the plasma membrane. Many components of the cortical cytoskeleton have been identified including structural and scaffolding proteins, membrane–cytoskeleton linker proteins and signaling intermediates. We describe here an association of the membrane-F-actin linker protein ezrin with the scaffolding protein IQGAP1 that serves as a hub for concentrating different signaling complexes. Both, ezrin and IQGAP1 bind in a Ca2 +-dependent manner to the EF hand protein S100P and complexes consisting of Ca2 +-bound S100P, IQGAP1 and ezrin can be isolated by immunoprecipitation. Ezrin and IQGAP1 also interact in the absence of Ca2 +, thus independent of S100P. Direct ezrin–IQGAP1 interaction can be shown with the purified proteins. It is mediated via the N-terminal FERM domain of ezrin and the IQ domain of IQGAP1, respectively. Ezrin and IQGAP1 colocalize in the submembraneous cytoskeleton and in cellular protrusions of human epithelial cells and knockdown of ezrin reduces the cortical localization of IQGAP1. Thus, ezrin appears to participate in recruiting IQGAP1 to the cell cortex thereby establishing a close connection between membrane-F-actin contacts and actin regulators that can be assembled by IQGAP1. This article is part of a Special Issue entitled: 13th European Symposium on Calcium." @default.
• W2037617680 created "2016-06-24" @default.
• W2037617680 creator A5006136975 @default.
• W2037617680 creator A5050435515 @default.
• W2037617680 creator A5077272649 @default.
• W2037617680 date "2015-09-01" @default.
• W2037617680 modified "2023-10-18" @default.
• W2037617680 title "Ezrin interacts with the scaffold protein IQGAP1 and affects its cortical localization" @default.
• W2037617680 cites W1965831400 @default.
• W2037617680 cites W1968393860 @default.
• W2037617680 cites W1970763876 @default.
• W2037617680 cites W1972110025 @default.
• W2037617680 cites W1998624086 @default.
• W2037617680 cites W2012400597 @default.
• W2037617680 cites W2025935519 @default.
• W2037617680 cites W2026260372 @default.
• W2037617680 cites W2035555613 @default.
• W2037617680 cites W2041012485 @default.
• W2037617680 cites W2042015318 @default.
• W2037617680 cites W2093375164 @default.
• W2037617680 cites W2095176131 @default.
• W2037617680 cites W2106677522 @default.
• W2037617680 cites W2111904037 @default.
• W2037617680 cites W2113773206 @default.
• W2037617680 cites W2114399401 @default.
• W2037617680 cites W2123404680 @default.
• W2037617680 cites W2133182203 @default.
• W2037617680 cites W2161888715 @default.
• W2037617680 cites W2172030715 @default.
• W2037617680 doi "https://doi.org/10.1016/j.bbamcr.2014.12.026" @default.
• W2037617680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25554515" @default.
• W2037617680 hasPublicationYear "2015" @default.
• W2037617680 type Work @default.
• W2037617680 sameAs 2037617680 @default.
• W2037617680 citedByCount "11" @default.
• W2037617680 countsByYear W20376176802016 @default.
• W2037617680 countsByYear W20376176802017 @default.
• W2037617680 countsByYear W20376176802019 @default.
• W2037617680 countsByYear W20376176802020 @default.
• W2037617680 countsByYear W20376176802021 @default.
• W2037617680 countsByYear W20376176802022 @default.
• W2037617680 countsByYear W20376176802023 @default.
• W2037617680 crossrefType "journal-article" @default.
• W2037617680 hasAuthorship W2037617680A5006136975 @default.
• W2037617680 hasAuthorship W2037617680A5050435515 @default.
• W2037617680 hasAuthorship W2037617680A5077272649 @default.
• W2037617680 hasBestOaLocation W20376176801 @default.
• W2037617680 hasConcept C125705527 @default.
• W2037617680 hasConcept C142669718 @default.
• W2037617680 hasConcept C1491633281 @default.
• W2037617680 hasConcept C185592680 @default.
• W2037617680 hasConcept C204462481 @default.
• W2037617680 hasConcept C2776292417 @default.
• W2037617680 hasConcept C2778106830 @default.
• W2037617680 hasConcept C2779560292 @default.
• W2037617680 hasConcept C2780246058 @default.
• W2037617680 hasConcept C2993400109 @default.
• W2037617680 hasConcept C49353375 @default.
• W2037617680 hasConcept C53645450 @default.
• W2037617680 hasConcept C55493867 @default.
• W2037617680 hasConcept C57581600 @default.
• W2037617680 hasConcept C62478195 @default.
• W2037617680 hasConcept C86803240 @default.
• W2037617680 hasConcept C95444343 @default.
• W2037617680 hasConceptScore W2037617680C125705527 @default.
• W2037617680 hasConceptScore W2037617680C142669718 @default.
• W2037617680 hasConceptScore W2037617680C1491633281 @default.
• W2037617680 hasConceptScore W2037617680C185592680 @default.
• W2037617680 hasConceptScore W2037617680C204462481 @default.
• W2037617680 hasConceptScore W2037617680C2776292417 @default.
• W2037617680 hasConceptScore W2037617680C2778106830 @default.
• W2037617680 hasConceptScore W2037617680C2779560292 @default.
• W2037617680 hasConceptScore W2037617680C2780246058 @default.
• W2037617680 hasConceptScore W2037617680C2993400109 @default.
• W2037617680 hasConceptScore W2037617680C49353375 @default.
• W2037617680 hasConceptScore W2037617680C53645450 @default.
• W2037617680 hasConceptScore W2037617680C55493867 @default.
• W2037617680 hasConceptScore W2037617680C57581600 @default.
• W2037617680 hasConceptScore W2037617680C62478195 @default.
• W2037617680 hasConceptScore W2037617680C86803240 @default.
• W2037617680 hasConceptScore W2037617680C95444343 @default.
• W2037617680 hasFunder F4320320879 @default.
• W2037617680 hasIssue "9" @default.
• W2037617680 hasLocation W20376176801 @default.
• W2037617680 hasLocation W20376176802 @default.
• W2037617680 hasOpenAccess W2037617680 @default.
• W2037617680 hasPrimaryLocation W20376176801 @default.
• W2037617680 hasRelatedWork W1965831400 @default.
• W2037617680 hasRelatedWork W1966704740 @default.
• W2037617680 hasRelatedWork W1992171856 @default.
• W2037617680 hasRelatedWork W2017663363 @default.
• W2037617680 hasRelatedWork W2037617680 @default.
• W2037617680 hasRelatedWork W2088739585 @default.
• W2037617680 hasRelatedWork W2109745607 @default.
• W2037617680 hasRelatedWork W2609902470 @default.
• W2037617680 hasRelatedWork W2999346730 @default.
• W2037617680 hasRelatedWork W3307581 @default.
• W2037617680 hasVolume "1853" @default.

• next