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• W2037640424 abstract "The aim of the present study was to compare the clinical and radiographic presentation as well as the therapeutic outcome of pulmonary tuberculosis (PT) in adult patients with and without human immunodeficiency virus type 1 (HIV-1) infection in Kigali, Rwanda. Over a 17-month period 59 consecutive patients with bacteriologically and/or histopathologically documented PT were enrolled. Of these, 48 (81%) patients were HIV seropositive. Among these, 35 fit the WHO clinical criteria for AIDS (WHOCCA) at the time of admission. Significant differences were found between the HIV-seropositive and HIV-seronegative groups of patients: fever (85 versus 36%; p less than 0.001), tuberculin skin test anergy (69 versus 0%; p less than 0.01), mediastinal and/or hilar adenopathies (31 versus 0%; p = 0.05), and pleural effusion (43 versus 9%; p less than 0.05) were more frequently encountered in the HIV-seropositive group, and upper lobe infiltrates (55 versus 16%; p less than 0.02) and cavitation (91 versus 39%; p less than 0.003) were more often seen in the HIV-seronegative group. However, HIV-seropositive patients not meeting WHOCCA were less frequently anergic (0 versus 100%; p less than 0.001) and feverish (53 versus 97%; p less than 0.01) and more often had cavitation (69 versus 28%; p less than 0.02) and less often mediastinal and/or hilar adenopathies (7 versus 40%; p less than 0.04) compared with HIV-seropositive patients meeting WHOCCA. Under antituberculosis treatment, clearance of fever was slower in HIV-seropositive compared with HIV-seronegative patients, and among the HIV-seropositive group it was slower in those fitting WHOCCA.(ABSTRACT TRUNCATED AT 250 WORDS)The aim of the present study was to compare the clinical and radiographic presentation as well as the therapeutic outcome of pulmonary tuberculosis (PT) in adult patients with and without human immunodeficiency virus type 1 (HIV-1) infection in Kigali, Rwanda. Over a 17-month period, 59 consecutive patients with bacteriologically and/or histopathologically documented PT were enrolled. Of these, 48 (81%) patients were HIV seropositive. Among these, 35 fit the WHO clinical criteria for AIDS (WHOCCA) at the time of admission. Significant differences were found between the HIV-seropositive and HIV-seronegative groups of patients: fever (85 vs. 36%; p0.001), tuberculin skin test energy (69 vs. 0%; p0.01), mediastinal and/or hilar adenopathies (31 vs. 0%; p=0.05), and pleural effusion (43 vs. 9%; p0.05) were more frequently encountered in the HIV-seropositive group, and upper lobe infiltrates (55 vs. 16%; p0.02) and cavitation (91 vs. 39%; p0.003) were more often seen in the HIV-seronegative group. However, HIV-seropositive patients who did not meet WHOCCA were less frequently anergic (1 vs. 100%; p0.001) and feverish (53 vs. 97% p0.01) and more often had cavitation (69 vs. 28%; p0.02) and less often mediastinal and/or hilar adenopathies (7 vs. 40%; p0.04) compared with HIV seropositive patients who met WHOCCA. Under antituberculosis treatment, clearance of fever was slower in HIV-seropositive compared with HIV-seronegative patients, and among the HIV-seropositive group, it was slower in those who fit WHOCCA. Data collected from this study suggest that the clinical severity and the radiographic pattern of Hiv-associated PT are strongly related to the degree of progression of HIV infection. Although slower in advanced HIV infection, a favorable response to antituberculosis treatment was seen in all these groups of patients." @default.
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• W2037640424 title "Pulmonary Tuberculosis in Kigali, Rwanda: Impact of Human Immunodeficiency Virus Infection on Clinical and Radiographic Presentation" @default.
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