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• W2037646922 abstract "The present investigation aimed at evaluating the use of different excipients, beta-lactose and polyvinylpyrrolidone of two molecular weights (PVP K12 and PVP K90), in the production of improved release piroxicam granules, by wet granulation using both water and steam as granulation liquid. The formulations examined were: piroxicam (Px)/beta-lactose; Px/PVP K12 and Px/PVP K90, each one at a 1:9 weight ratio. The most significant difference between beta-lactose and PVP is that, using the first excipient, both steam and water granules were produced while, when PVP were employed, only steam granules were obtained. Image analysis revealed that beta-lactose steam granules had a larger surface area with respect to water granules, whereas lower values of this parameter were observed in PVP-s granules, confirming the Scanning Electron Microscopy micrographs and the fractal analysis results. As regards the enhancement of the dissolution profiles, the best result was obtained using beta-lactose steam granules followed by PVP K12 ones, even if the reactive dimension values indicated that during the dissolution process PVP K12 granules modified the surface more than beta-lactose granules. As regards PVP K90, this excipient was the one less influencing the granule morphology and the dissolution behaviour. Differential Scanning Calorimetry analysis suggested the partial amorphisation of the drug in the granules containing the three excipients. This result was then confirmed by X-ray powder diffraction analysis. Therefore, beta-lactose and PVP K12 could be proposed as useful excipients to enhance the dissolution rate of Px from granules prepared using the steam granulation technique." @default.
• W2037646922 created "2016-06-24" @default.
• W2037646922 creator A5035196058 @default.
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• W2037646922 creator A5051641449 @default.
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• W2037646922 creator A5061291191 @default.
• W2037646922 date "2003-11-01" @default.
• W2037646922 modified "2023-10-16" @default.
• W2037646922 title "Evaluation of β-lactose, PVP K12 and PVP K90 as excipients to prepare piroxicam granules using two wet granulation techniques" @default.
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• W2037646922 doi "https://doi.org/10.1016/s0939-6411(03)00114-0" @default.
• W2037646922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14602193" @default.
• W2037646922 hasPublicationYear "2003" @default.
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