Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037647570> ?p ?o ?g. }
- W2037647570 endingPage "450" @default.
- W2037647570 startingPage "438" @default.
- W2037647570 abstract "As bona fide p53 transcriptional targets, miR-34 microRNAs (miRNAs) exhibit frequent alterations in many human tumor types and elicit multiple p53 downstream effects upon overexpression. Unexpectedly, miR-34 deletion alone fails to impair multiple p53-mediated tumor suppressor effects in mice, possibly due to the considerable redundancy in the p53 pathway. Here, we demonstrate that miR-34a represses HDM4 , a potent negative regulator of p53, creating a positive feedback loop acting on p53. In a Kras -induced mouse lung cancer model, miR-34a deficiency alone does not exhibit a strong oncogenic effect. However, miR-34a deficiency strongly promotes tumorigenesis when p53 is haploinsufficient, suggesting that the defective p53– miR-34 feedback loop can enhance oncogenesis in a specific context. The importance of the p53/ miR-34 /HDM4 feedback loop is further confirmed by an inverse correlation between miR-34 and full-length HDM4 in human lung adenocarcinomas. In addition, human lung adenocarcinomas generate an elevated level of a short HDM4 isoform through alternative polyadenylation. This short HDM4 isoform lacks miR-34 -binding sites in the 3′ untranslated region (UTR), thereby evading miR-34 regulation to disable the p53- miR-34 positive feedback. Taken together, our results elucidated the intricate cross-talk between p53 and miR-34 miRNAs and revealed an important tumor suppressor effect generated by this positive feedback loop." @default.
- W2037647570 created "2016-06-24" @default.
- W2037647570 creator A5009163241 @default.
- W2037647570 creator A5009912547 @default.
- W2037647570 creator A5020280119 @default.
- W2037647570 creator A5022771649 @default.
- W2037647570 creator A5029202750 @default.
- W2037647570 creator A5037643399 @default.
- W2037647570 creator A5039059766 @default.
- W2037647570 creator A5042932744 @default.
- W2037647570 creator A5053239891 @default.
- W2037647570 creator A5055929035 @default.
- W2037647570 creator A5081064913 @default.
- W2037647570 creator A5083310205 @default.
- W2037647570 creator A5084204471 @default.
- W2037647570 creator A5084397317 @default.
- W2037647570 date "2014-02-14" @default.
- W2037647570 modified "2023-10-17" @default.
- W2037647570 title "A positive feedback between p53 and <i>miR-34</i> miRNAs mediates tumor suppression" @default.
- W2037647570 cites W1598779357 @default.
- W2037647570 cites W1963872465 @default.
- W2037647570 cites W1964719993 @default.
- W2037647570 cites W1967834923 @default.
- W2037647570 cites W1973748124 @default.
- W2037647570 cites W1975437957 @default.
- W2037647570 cites W1976295398 @default.
- W2037647570 cites W1984187829 @default.
- W2037647570 cites W1985064409 @default.
- W2037647570 cites W1988425997 @default.
- W2037647570 cites W1990291815 @default.
- W2037647570 cites W1992638032 @default.
- W2037647570 cites W1994772304 @default.
- W2037647570 cites W1998445975 @default.
- W2037647570 cites W2006173503 @default.
- W2037647570 cites W2014946489 @default.
- W2037647570 cites W2018383450 @default.
- W2037647570 cites W2025722611 @default.
- W2037647570 cites W2030120875 @default.
- W2037647570 cites W2031475327 @default.
- W2037647570 cites W2032019019 @default.
- W2037647570 cites W2038167014 @default.
- W2037647570 cites W2048434787 @default.
- W2037647570 cites W2052994887 @default.
- W2037647570 cites W2059073003 @default.
- W2037647570 cites W2059848983 @default.
- W2037647570 cites W2063878022 @default.
- W2037647570 cites W2067411546 @default.
- W2037647570 cites W2069167711 @default.
- W2037647570 cites W2070032322 @default.
- W2037647570 cites W2083381199 @default.
- W2037647570 cites W2085252210 @default.
- W2037647570 cites W2119337308 @default.
- W2037647570 cites W2119709711 @default.
- W2037647570 cites W2126832141 @default.
- W2037647570 cites W2133959309 @default.
- W2037647570 cites W2142180745 @default.
- W2037647570 cites W2144154026 @default.
- W2037647570 cites W2146040216 @default.
- W2037647570 cites W2155487079 @default.
- W2037647570 cites W2156843318 @default.
- W2037647570 cites W2158811981 @default.
- W2037647570 cites W2159793493 @default.
- W2037647570 cites W2160368760 @default.
- W2037647570 cites W2162674813 @default.
- W2037647570 cites W2163199119 @default.
- W2037647570 cites W2337358073 @default.
- W2037647570 doi "https://doi.org/10.1101/gad.233585.113" @default.
- W2037647570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3950342" @default.
- W2037647570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24532687" @default.
- W2037647570 hasPublicationYear "2014" @default.
- W2037647570 type Work @default.
- W2037647570 sameAs 2037647570 @default.
- W2037647570 citedByCount "243" @default.
- W2037647570 countsByYear W20376475702014 @default.
- W2037647570 countsByYear W20376475702015 @default.
- W2037647570 countsByYear W20376475702016 @default.
- W2037647570 countsByYear W20376475702017 @default.
- W2037647570 countsByYear W20376475702018 @default.
- W2037647570 countsByYear W20376475702019 @default.
- W2037647570 countsByYear W20376475702020 @default.
- W2037647570 countsByYear W20376475702021 @default.
- W2037647570 countsByYear W20376475702022 @default.
- W2037647570 countsByYear W20376475702023 @default.
- W2037647570 crossrefType "journal-article" @default.
- W2037647570 hasAuthorship W2037647570A5009163241 @default.
- W2037647570 hasAuthorship W2037647570A5009912547 @default.
- W2037647570 hasAuthorship W2037647570A5020280119 @default.
- W2037647570 hasAuthorship W2037647570A5022771649 @default.
- W2037647570 hasAuthorship W2037647570A5029202750 @default.
- W2037647570 hasAuthorship W2037647570A5037643399 @default.
- W2037647570 hasAuthorship W2037647570A5039059766 @default.
- W2037647570 hasAuthorship W2037647570A5042932744 @default.
- W2037647570 hasAuthorship W2037647570A5053239891 @default.
- W2037647570 hasAuthorship W2037647570A5055929035 @default.
- W2037647570 hasAuthorship W2037647570A5081064913 @default.
- W2037647570 hasAuthorship W2037647570A5083310205 @default.
- W2037647570 hasAuthorship W2037647570A5084204471 @default.
- W2037647570 hasAuthorship W2037647570A5084397317 @default.