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• W2037648198 abstract "Although atrial natriuretic peptide (ANP) has recently been verified to function as a neuropeptide in the central nervous system, its definite identification has not been done so far. We have isolated two ANP-related peptides from porcine brain by utilizing alpha-ANP specific radiommunoassay coupled with immunoaffinity chromatography and reverse phase HPLC. By structural analyses, these two peptides were determined to be alpha-ANP [4-28] and alpha-ANP [5-28]. They were found to elicit chick rectum relaxant activity comparable to alpha-ANP. These results indicate that proteolytic processing of ANP precursor in the central nervous system takes place in a manner different from that in heart and plasma, where gamma-ANP and alpha-ANP are known to be the main components of ANP, respectively." @default.
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• W2037648198 date "1987-12-01" @default.
• W2037648198 modified "2023-10-16" @default.
• W2037648198 title "Identification of alpha atrial natriuretic peptide [4–28] and [5–28] in porcine brain" @default.
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• W2037648198 doi "https://doi.org/10.1016/0006-291x(87)90515-8" @default.
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