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- W2037654596 abstract "Superhelical pBR322 DNA has been photosensitized in the presence of various promazine derivatives. Agarose gel electrophoresis of the photosensitized DNA reveals that true single-strand breaks are induced during irradiation. Alkaline treatment of the photosensitized DNA with a subsequent alkaline agarose gel electrophoresis demonstrates that in addition to true single-strand breaks, these drugs can induce alkali-labile lesions. Although true single-strand breaks are induced randomly into a 5'-[32P]-end labeled pBR322 DNA fragments, the alkaline-labile alterations are located specifically at the level of guanine residues. A strong correlation seems to exist between the visualization of this labilization and the induction of a covalent photoadduct on guanine by the photosensitization mediated by PZ." @default.
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- W2037654596 date "1987-11-01" @default.
- W2037654596 modified "2023-09-24" @default.
- W2037654596 title "Alkaline labilization of DNA photosensitized by promazine derivatives" @default.
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- W2037654596 doi "https://doi.org/10.1016/0006-2952(87)90023-2" @default.
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