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- W2037656268 abstract "Ingestion of surfactants is known to cause hemodynamic changes with decreased total vascular resistance. Motivated by this clinical observation, we investigated the direct effects of a common anionic surfactant, sodium polyoxyethylene laurylether sulfate (LES), on isolated ring segments of rat thoracic aorta. LES did not produce any vasocontractile responses, but relaxed ring segments precontracted with 10−6mphenylephrine in a concentration-dependent manner. This LES-induced vasorelaxation was significantly reduced by the removal of endothelium or pretreatment withNG-nitro-l-arginine methylester hydrochloride, methylene blue, or oxyhemoglobin to the same degree, but was not affected by pretreatment with indomethacin. A further study measuringNO2−plusNO3−(NOx, total metabolites of NO) in the medium of calf pulmonary artery endothelial (CPAE) cells, a cultured cell line, revealed that LES caused a significant increase in NOxproduction. On the other hand, in a study measuring intracellular Ca2+in fura-2-loaded CPAE cells, LES caused a significant increase in intracellular Ca2+. These results suggest that LES causes endothelium-dependent vasorelaxation via a NO-mediated signaling pathway, which might be due to Ca2+mobilization." @default.
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- W2037656268 title "Nitric Oxide-Mediated Vasorelaxation Induced by Sodium Polyoxyethylene Laurylether Sulfate" @default.
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- W2037656268 doi "https://doi.org/10.1006/taap.1997.8192" @default.
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