FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037661666> ?p ?o ?g. }

• W2037661666 endingPage "697" @default.
• W2037661666 startingPage "690" @default.
• W2037661666 abstract "The terminal respiratory enzyme cytochrome c oxidase (CcO) reduces molecular oxygen to water, and pumps protons across the inner mitochondrial membrane, or the plasma membrane of bacteria. A two-subunit CcO harbors all the elements necessary for oxygen reduction and proton pumping. However, it rapidly undergoes turnover-induced irreversible damage, which is effectively prevented by the presence of subunit III and its tightly bound lipids. We have performed classical atomistic molecular dynamics (MD) simulations on a three-subunit CcO, which show the formation of water wires between the polar head groups of lipid molecules bound to subunit III and the proton uptake site Asp91 (Bos taurus enzyme numbering). Continuum electrostatic calculations suggest that these lipids directly influence the proton affinity of Asp91 by 1–2 pK units. We surmise that lipids bound to subunit III influence the rate of proton uptake through the D-pathway, and therefore play a key role in preventing turnover-induced inactivation. Atomistic MD simulations show that subunit III is rapidly hydrated in the absence of internally bound lipids, which is likely to affect the rate of O2 diffusion into the active-site. The role of subunit III with its indigenous lipids in the molecular mechanism of CcO is discussed." @default.
• W2037661666 created "2016-06-24" @default.
• W2037661666 creator A5000095767 @default.
• W2037661666 creator A5029212835 @default.
• W2037661666 creator A5080823205 @default.
• W2037661666 creator A5082983574 @default.
• W2037661666 creator A5091246390 @default.
• W2037661666 date "2015-08-01" @default.
• W2037661666 modified "2023-10-03" @default.
• W2037661666 title "Role of subunit III and its lipids in the molecular mechanism of cytochrome c oxidase" @default.
• W2037661666 cites W1898563571 @default.
• W2037661666 cites W1965962622 @default.
• W2037661666 cites W1967624352 @default.
• W2037661666 cites W1967888351 @default.
• W2037661666 cites W1970257190 @default.
• W2037661666 cites W1972005066 @default.
• W2037661666 cites W1978808231 @default.
• W2037661666 cites W1989476085 @default.
• W2037661666 cites W1993725730 @default.
• W2037661666 cites W1993871971 @default.
• W2037661666 cites W1994008677 @default.
• W2037661666 cites W1994732772 @default.
• W2037661666 cites W1995929558 @default.
• W2037661666 cites W1995936115 @default.
• W2037661666 cites W2001806196 @default.
• W2037661666 cites W2009239636 @default.
• W2037661666 cites W2012796348 @default.
• W2037661666 cites W2013779642 @default.
• W2037661666 cites W2026099703 @default.
• W2037661666 cites W2027408247 @default.
• W2037661666 cites W2029038325 @default.
• W2037661666 cites W2029667189 @default.
• W2037661666 cites W2031227547 @default.
• W2037661666 cites W2037607943 @default.
• W2037661666 cites W2038361800 @default.
• W2037661666 cites W2040177933 @default.
• W2037661666 cites W2044942656 @default.
• W2037661666 cites W2045825349 @default.
• W2037661666 cites W2054167577 @default.
• W2037661666 cites W2061525480 @default.
• W2037661666 cites W2066683823 @default.
• W2037661666 cites W2067174909 @default.
• W2037661666 cites W2071280670 @default.
• W2037661666 cites W2079108392 @default.
• W2037661666 cites W2079243965 @default.
• W2037661666 cites W2084362586 @default.
• W2037661666 cites W2094042540 @default.
• W2037661666 cites W2097123168 @default.
• W2037661666 cites W2101053825 @default.
• W2037661666 cites W2133885246 @default.
• W2037661666 cites W2145450694 @default.
• W2037661666 cites W2149773634 @default.
• W2037661666 cites W2150264392 @default.
• W2037661666 cites W2150981663 @default.
• W2037661666 cites W2157859603 @default.
• W2037661666 cites W2161080023 @default.
• W2037661666 cites W2162227013 @default.
• W2037661666 cites W2163003488 @default.
• W2037661666 cites W2166258960 @default.
• W2037661666 cites W2319752835 @default.
• W2037661666 cites W2319947735 @default.
• W2037661666 cites W4247605598 @default.
• W2037661666 cites W4250894480 @default.
• W2037661666 doi "https://doi.org/10.1016/j.bbabio.2015.04.007" @default.
• W2037661666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25896562" @default.
• W2037661666 hasPublicationYear "2015" @default.
• W2037661666 type Work @default.
• W2037661666 sameAs 2037661666 @default.
• W2037661666 citedByCount "24" @default.
• W2037661666 countsByYear W20376616662016 @default.
• W2037661666 countsByYear W20376616662017 @default.
• W2037661666 countsByYear W20376616662018 @default.
• W2037661666 countsByYear W20376616662019 @default.
• W2037661666 countsByYear W20376616662020 @default.
• W2037661666 countsByYear W20376616662021 @default.
• W2037661666 countsByYear W20376616662022 @default.
• W2037661666 crossrefType "journal-article" @default.
• W2037661666 hasAuthorship W2037661666A5000095767 @default.
• W2037661666 hasAuthorship W2037661666A5029212835 @default.
• W2037661666 hasAuthorship W2037661666A5080823205 @default.
• W2037661666 hasAuthorship W2037661666A5082983574 @default.
• W2037661666 hasAuthorship W2037661666A5091246390 @default.
• W2037661666 hasConcept C104292427 @default.
• W2037661666 hasConcept C104317684 @default.
• W2037661666 hasConcept C123249941 @default.
• W2037661666 hasConcept C12554922 @default.
• W2037661666 hasConcept C147597530 @default.
• W2037661666 hasConcept C181199279 @default.
• W2037661666 hasConcept C185592680 @default.
• W2037661666 hasConcept C2909484822 @default.
• W2037661666 hasConcept C3020377403 @default.
• W2037661666 hasConcept C38485361 @default.
• W2037661666 hasConcept C55493867 @default.
• W2037661666 hasConcept C59593255 @default.
• W2037661666 hasConcept C71240020 @default.
• W2037661666 hasConcept C86803240 @default.
• W2037661666 hasConceptScore W2037661666C104292427 @default.
• W2037661666 hasConceptScore W2037661666C104317684 @default.

• next