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- W2037662288 abstract "Methods: We assessed outcomes of pts who underwent PCI for STEMI using RA vs. FA in the HORIZONS-AMI trial. Of 3,334 pts randomized to bivalirudin vs. to UFH + a GPIIb/IIIa inhibitor (GPI), PCI by operator choice was performed by the FA and RA in 3134 (94.0%) and 200 (6.0%) pts, respectively. Results: Pts treated by FA vs. RA tended to be older, with higher rates of smoking, hyperlipidemia, prior CABG, and lower baseline creatinine clearance and platelet count. RA was associated with signiicant reduction in 30-day major and minor bleeding due to reductions in both major hemorrhagic events and large hematomas. By multivariable analysis, RA (vs. FA) was an independent predictor of freedom from non-CABG major bleeding at 30 days (HR 0.40; 95% CI [0.18, 0.90]; p=0.03). Conclusions: In the large-scale, international HORIZONS-AMI trial, performance of primary PCI by the RA rather than the FA was infrequent, and was selected in younger STEMI pts with fewer comorbidities. Primary PCI using the RA was associated with reduced hemorrhagic complications compared to the FA. A randomized trial is required to determine the generalizability and advantages of this approach. 30 day events, % Radial (N=200)" @default.
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- W2037662288 date "2010-03-01" @default.
- W2037662288 modified "2023-09-24" @default.
- W2037662288 title "TRANSRADIAL VS. TRANSFEMORAL APPROACH FOR PRIMARY ANGIOPLASTY IN ACUTE MYOCARDIAL INFARCTION: ANALYSIS FROM THE HORIZONS-AMI TRIAL." @default.
- W2037662288 doi "https://doi.org/10.1016/s0735-1097(10)61736-6" @default.
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