FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037668299> ?p ?o ?g. }

• W2037668299 endingPage "252" @default.
• W2037668299 startingPage "237" @default.
• W2037668299 abstract "The neuropeptide melanin concentrating hormone (MCH) is synthesised only by neurons of the lateral hypothalamic (LH) area in the CNS. MCH cells project widely throughout the brain. Despite the growing interest in this peptide, in part related to its role in feeding, little has been done to characterise its physiological effects in neurons. Using whole-cell recording with current and voltage clamp, we examined the cellular actions in neurons from the LH. MCH induced a consistent decrease in the frequency of action potentials and reduced synaptic activity. Most fast synaptic activity in the hypothalamus is mediated by GABA or glutamate. MCH inhibited the synaptic activity of both glutamatergic and GABAergic LH neurons, each tested independently. MCH reduced the amplitude of glutamate-evoked currents and reduced the amplitude of miniature excitatory currents, indicating an inhibitory modulation of postsynaptic glutamate receptors. In the presence of tetrodotoxin to block action potentials, MCH caused a depression in the frequency of miniature glutamate-mediated postsynaptic currents, suggesting a presynaptic site of receptor expression. In voltage clamp experiments, MCH depressed the amplitude of calcium currents, suggesting that a mechanism of inhibition may involve a reduced calcium-dependent release of amino acid transmitter. Previous reports have suggested that MCH activated potassium channels in non-neuronal cells transfected with the MCH receptor gene. We found no effect of MCH on voltage-dependent potassium channels in LH neurons. Baclofen, a GABAB receptor agonist, activated G-protein gated inwardly rectifying potassium (GIRK)-type channels; in the same neurons, MCH had no effect on GIRK channels. MCH showed no modulation of sodium currents. Blockade of the Gi/Go protein with pertussis toxin eliminated the actions of MCH. The inhibitory actions of MCH on both excitatory and inhibitory synaptic events, coupled with opposing excitatory actions of hypocretin, another LH peptide that projects to many of the same loci, suggest a substantial level of complexity in neuropeptide modulation of LH actions." @default.
• W2037668299 created "2016-06-24" @default.
• W2037668299 creator A5003320362 @default.
• W2037668299 creator A5004172478 @default.
• W2037668299 date "2001-05-01" @default.
• W2037668299 modified "2023-10-18" @default.
• W2037668299 title "Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus" @default.
• W2037668299 cites W1481893565 @default.
• W2037668299 cites W1485682868 @default.
• W2037668299 cites W1519232679 @default.
• W2037668299 cites W1570789308 @default.
• W2037668299 cites W1579647545 @default.
• W2037668299 cites W1583982978 @default.
• W2037668299 cites W1625842445 @default.
• W2037668299 cites W1627229807 @default.
• W2037668299 cites W1671279920 @default.
• W2037668299 cites W1703545573 @default.
• W2037668299 cites W1838416155 @default.
• W2037668299 cites W1866757404 @default.
• W2037668299 cites W1880527760 @default.
• W2037668299 cites W1893009693 @default.
• W2037668299 cites W1951786929 @default.
• W2037668299 cites W1959892192 @default.
• W2037668299 cites W1970310579 @default.
• W2037668299 cites W1978082185 @default.
• W2037668299 cites W1979842004 @default.
• W2037668299 cites W1983298714 @default.
• W2037668299 cites W1993137505 @default.
• W2037668299 cites W2005262731 @default.
• W2037668299 cites W2010720720 @default.
• W2037668299 cites W2017155412 @default.
• W2037668299 cites W2020098765 @default.
• W2037668299 cites W2020911593 @default.
• W2037668299 cites W2023946490 @default.
• W2037668299 cites W2027171495 @default.
• W2037668299 cites W2027180375 @default.
• W2037668299 cites W2027740042 @default.
• W2037668299 cites W2030257170 @default.
• W2037668299 cites W2041677480 @default.
• W2037668299 cites W2043210544 @default.
• W2037668299 cites W2049088920 @default.
• W2037668299 cites W2056234109 @default.
• W2037668299 cites W2056281014 @default.
• W2037668299 cites W2057012057 @default.
• W2037668299 cites W2065565019 @default.
• W2037668299 cites W2066503167 @default.
• W2037668299 cites W2067039618 @default.
• W2037668299 cites W2070025492 @default.
• W2037668299 cites W2072154498 @default.
• W2037668299 cites W2073148375 @default.
• W2037668299 cites W2074730021 @default.
• W2037668299 cites W2077944067 @default.
• W2037668299 cites W2080660424 @default.
• W2037668299 cites W2091475951 @default.
• W2037668299 cites W2093013340 @default.
• W2037668299 cites W2093098283 @default.
• W2037668299 cites W2094046904 @default.
• W2037668299 cites W2099522758 @default.
• W2037668299 cites W2100379739 @default.
• W2037668299 cites W2109067572 @default.
• W2037668299 cites W2109208582 @default.
• W2037668299 cites W2111031293 @default.
• W2037668299 cites W2115902692 @default.
• W2037668299 cites W2121035876 @default.
• W2037668299 cites W2122301924 @default.
• W2037668299 cites W2127079625 @default.
• W2037668299 cites W2132682899 @default.
• W2037668299 cites W2136690680 @default.
• W2037668299 cites W2152211310 @default.
• W2037668299 cites W2164357952 @default.
• W2037668299 cites W2169378022 @default.
• W2037668299 cites W22056160 @default.
• W2037668299 cites W2408041505 @default.
• W2037668299 cites W2414806773 @default.
• W2037668299 cites W2579401595 @default.
• W2037668299 doi "https://doi.org/10.1111/j.1469-7793.2001.0237b.x" @default.
• W2037668299 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2278620" @default.
• W2037668299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11351031" @default.
• W2037668299 hasPublicationYear "2001" @default.
• W2037668299 type Work @default.
• W2037668299 sameAs 2037668299 @default.
• W2037668299 citedByCount "171" @default.
• W2037668299 countsByYear W20376682992012 @default.
• W2037668299 countsByYear W20376682992013 @default.
• W2037668299 countsByYear W20376682992014 @default.
• W2037668299 countsByYear W20376682992015 @default.
• W2037668299 countsByYear W20376682992017 @default.
• W2037668299 countsByYear W20376682992018 @default.
• W2037668299 countsByYear W20376682992019 @default.
• W2037668299 countsByYear W20376682992020 @default.
• W2037668299 countsByYear W20376682992021 @default.
• W2037668299 countsByYear W20376682992022 @default.
• W2037668299 countsByYear W20376682992023 @default.
• W2037668299 crossrefType "journal-article" @default.
• W2037668299 hasAuthorship W2037668299A5003320362 @default.
• W2037668299 hasAuthorship W2037668299A5004172478 @default.
• W2037668299 hasBestOaLocation W20376682992 @default.
• W2037668299 hasConcept C112592302 @default.

• next