FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037668892> ?p ?o ?g. }

• W2037668892 endingPage "47" @default.
• W2037668892 startingPage "37" @default.
• W2037668892 abstract "Epidermal neural crest stem cells (EPI-NCSCs), which reside in the bulge of hair follicles, are attractive candidates for several applications in cell therapy, drug screening and tissue engineering. As suggested remnants of the embryonic neural crest (NC) in an adult location, EPI-NCSCs are able to generate a wide variety of cell types and are readily accessible by a minimally invasive procedure. Since the combination of epidermal growth factor (EGF) and fibroblast growth factor type 2 (FGF2) is mitogenic and promotes the neuronal commitment of various stem cell populations, we examined its effects in the proliferation and neuronal potential of mouse EPI-NCSCs. By using a recognized culture protocol of bulge whiskers follicles, we were able to isolate a population of EPI-NCSCs, characterized by the migratory potential, cell morphology and expression of phenotypic markers of NC cells. EPI-NCSCs expressed neuronal, glial and smooth muscle markers and exhibited the NC-like fibroblastic morphology. The treatment with the combination EGF and FGF2, however, increased their proliferation rate and promoted the acquisition of a neuronal-like morphology accompanied by reorganization of neural cytoskeletal proteins βIII-tubulin and nestin, as well as upregulation of the pan neuronal marker βIII-tubulin and down regulation of the undifferentiated NC, glial and smooth muscle cell markers. Moreover, the treatment enhanced the response of EPI-NCSCs to neurogenic stimulation, as evidenced by induction of GAP43, and increased expression of Mash-1 in neuron-like cell, both neuronal-specific proteins. Together, the results suggest that the combination of EGF-FGF2 stimulates the proliferation and improves the neuronal potential of EPI-NCSCs similarly to embryonic NC cells, ES cells and neural progenitor/stem cells of the central nervous system and highlights the advantage of using EGF-FGF2 in neuronal differentiation protocols." @default.
• W2037668892 created "2016-06-24" @default.
• W2037668892 creator A5011314156 @default.
• W2037668892 creator A5030448174 @default.
• W2037668892 creator A5036963787 @default.
• W2037668892 creator A5037280500 @default.
• W2037668892 creator A5070952159 @default.
• W2037668892 creator A5081869157 @default.
• W2037668892 creator A5084032651 @default.
• W2037668892 creator A5090527549 @default.
• W2037668892 creator A5091739245 @default.
• W2037668892 date "2014-09-01" @default.
• W2037668892 modified "2023-10-09" @default.
• W2037668892 title "EGF–FGF2 stimulates the proliferation and improves the neuronal commitment of mouse epidermal neural crest stem cells (EPI-NCSCs)" @default.
• W2037668892 cites W1906779471 @default.
• W2037668892 cites W1920934924 @default.
• W2037668892 cites W1969741234 @default.
• W2037668892 cites W1981254350 @default.
• W2037668892 cites W1985322254 @default.
• W2037668892 cites W2010749425 @default.
• W2037668892 cites W2018235103 @default.
• W2037668892 cites W2020830179 @default.
• W2037668892 cites W2026048262 @default.
• W2037668892 cites W2031616424 @default.
• W2037668892 cites W2043434030 @default.
• W2037668892 cites W2043950060 @default.
• W2037668892 cites W2046885093 @default.
• W2037668892 cites W2060503160 @default.
• W2037668892 cites W2079356804 @default.
• W2037668892 cites W2080636637 @default.
• W2037668892 cites W2080930253 @default.
• W2037668892 cites W2081121476 @default.
• W2037668892 cites W2084150404 @default.
• W2037668892 cites W2087211932 @default.
• W2037668892 cites W2108760842 @default.
• W2037668892 cites W2135207143 @default.
• W2037668892 cites W2138921976 @default.
• W2037668892 cites W2141310245 @default.
• W2037668892 cites W2150014868 @default.
• W2037668892 cites W2151011478 @default.
• W2037668892 doi "https://doi.org/10.1016/j.yexcr.2014.05.020" @default.
• W2037668892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24907656" @default.
• W2037668892 hasPublicationYear "2014" @default.
• W2037668892 type Work @default.
• W2037668892 sameAs 2037668892 @default.
• W2037668892 citedByCount "29" @default.
• W2037668892 countsByYear W20376688922014 @default.
• W2037668892 countsByYear W20376688922015 @default.
• W2037668892 countsByYear W20376688922016 @default.
• W2037668892 countsByYear W20376688922017 @default.
• W2037668892 countsByYear W20376688922018 @default.
• W2037668892 countsByYear W20376688922019 @default.
• W2037668892 countsByYear W20376688922020 @default.
• W2037668892 countsByYear W20376688922021 @default.
• W2037668892 countsByYear W20376688922022 @default.
• W2037668892 crossrefType "journal-article" @default.
• W2037668892 hasAuthorship W2037668892A5011314156 @default.
• W2037668892 hasAuthorship W2037668892A5030448174 @default.
• W2037668892 hasAuthorship W2037668892A5036963787 @default.
• W2037668892 hasAuthorship W2037668892A5037280500 @default.
• W2037668892 hasAuthorship W2037668892A5070952159 @default.
• W2037668892 hasAuthorship W2037668892A5081869157 @default.
• W2037668892 hasAuthorship W2037668892A5084032651 @default.
• W2037668892 hasAuthorship W2037668892A5090527549 @default.
• W2037668892 hasAuthorship W2037668892A5091739245 @default.
• W2037668892 hasConcept C104317684 @default.
• W2037668892 hasConcept C126749454 @default.
• W2037668892 hasConcept C136302470 @default.
• W2037668892 hasConcept C136834591 @default.
• W2037668892 hasConcept C145103041 @default.
• W2037668892 hasConcept C162746124 @default.
• W2037668892 hasConcept C170493617 @default.
• W2037668892 hasConcept C196843134 @default.
• W2037668892 hasConcept C20875687 @default.
• W2037668892 hasConcept C2776362946 @default.
• W2037668892 hasConcept C28328180 @default.
• W2037668892 hasConcept C54355233 @default.
• W2037668892 hasConcept C74373430 @default.
• W2037668892 hasConcept C81885089 @default.
• W2037668892 hasConcept C86803240 @default.
• W2037668892 hasConcept C95444343 @default.
• W2037668892 hasConceptScore W2037668892C104317684 @default.
• W2037668892 hasConceptScore W2037668892C126749454 @default.
• W2037668892 hasConceptScore W2037668892C136302470 @default.
• W2037668892 hasConceptScore W2037668892C136834591 @default.
• W2037668892 hasConceptScore W2037668892C145103041 @default.
• W2037668892 hasConceptScore W2037668892C162746124 @default.
• W2037668892 hasConceptScore W2037668892C170493617 @default.
• W2037668892 hasConceptScore W2037668892C196843134 @default.
• W2037668892 hasConceptScore W2037668892C20875687 @default.
• W2037668892 hasConceptScore W2037668892C2776362946 @default.
• W2037668892 hasConceptScore W2037668892C28328180 @default.
• W2037668892 hasConceptScore W2037668892C54355233 @default.
• W2037668892 hasConceptScore W2037668892C74373430 @default.
• W2037668892 hasConceptScore W2037668892C81885089 @default.
• W2037668892 hasConceptScore W2037668892C86803240 @default.
• W2037668892 hasConceptScore W2037668892C95444343 @default.
• W2037668892 hasIssue "1" @default.

• next