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- W2037676502 abstract "Inferior alveolar nerve (IAN) injury is a concern in mandible distraction osteogenesis (DO). We have previously demonstrated that repeated local injections of human nerve growth factor β (NGF-β) have significantly enhanced the histologic recovery of the IAN in a rabbit model of DO. This study was to further test the effect of a single injection of human NGF-β delivered via a collagen/nanohydroxyapatite/κ-carrageenan gel to the recovery of the IAN in DO. Rabbits underwent mandibular DO at a rate of 0.75 mm/12 h for 6 days. At the end of the distraction period, injections were performed near the IAN percutaneously as follows: group 1, human NGF-β in the gel; group 2, human NGF-β in saline; group 3, the gel alone; and group 4, saline alone. At 14 days after the end of distraction, IAN histologic findings and histomorphometric parameters were evaluated. Histologically, there were less myelin debris and more abundant regenerating nerve fibers in group 1 than the other groups. Both the myelinated fiber density and the myelinated axon area in group 1 were significantly higher than groups 3 and 4 (P < 0.01); the myelinated axon area in the group 1 was significantly higher than group 2 (P < 0.01). In conclusion, the delivery of human NGF-β in the gel leads to a better acceleration of the IAN injury recovery over the saline delivery. It provides a possible way to enhance the recovery of nerve injuries in craniofacial DO clinically." @default.
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- W2037676502 date "2009-11-01" @default.
- W2037676502 modified "2023-09-25" @default.
- W2037676502 title "Effects of Nerve Growth Factor Delivery Via a Gel to Inferior Alveolar Nerve in Mandibular Distraction Osteogenesis" @default.
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- W2037676502 doi "https://doi.org/10.1097/scs.0b013e3181bf04c7" @default.
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