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• W2037683757 abstract "Polycyclic aromatic hydrocarbons (PAHs) are considered to be significant environmental carcinogens. Additionally, various planar ring systems are capable of intercalating with DNA, leading to a number of drugs that possess chemotherapeutic activity. In this study, three new polyaromatic compounds with a side chain were synthesized, and spectroscopic as well as elemental analyses were performed. The addition of the long chains to either chrysene or pyrene caused a red-shift in the spectral emission when compared to the corresponding polycyclic aromatic hydrocarbons itself. Furthermore, the cytotoxicity of the three novel polyaromatic compounds was evaluated in vitro in a panel of cultured mammalian cell lines. The pyrenyl ether demonstrated better cytotoxicity compared to cisplatin against colon (HT-29) as well as cervical (HeLa) cancer cell lines. In conclusion, three new compounds were synthesized and investigated in this study. This novel method is likely to play a role in other areas of research." @default.
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• W2037683757 date "2011-10-04" @default.
• W2037683757 modified "2023-10-14" @default.
• W2037683757 title "Polycyclic aromatic compounds as anticancer agents: Evaluation of synthesis and in vitro cytotoxicity" @default.
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• W2037683757 doi "https://doi.org/10.3892/ol.2011.436" @default.
• W2037683757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3362437" @default.
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