Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037695759> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2037695759 endingPage "2674" @default.
- W2037695759 startingPage "2668" @default.
- W2037695759 abstract "There are 94,709 clinical trials across 179 countries. Approximately half (47,467) are related to the three categories within the scope of the free online resource Drug Delivery Trends in Clinical Trials and Translational Medicine, which are (1) drug delivery technology and systems, (2) biological molecule platforms, and (3) pharmacokinetic and pharmacodynamic interactions. In this commentary, trends in biological molecule platforms and their impacts are discussed. The sales of top 15 biologic drugs have reached over $63 billion in 2010. In the past 10 years, major pharmaceutical companies have acquired biological molecule platforms and have become integrated biopharmaceutical companies, highlighting the role of biotechnology in driving new therapeutic product development. The top three products--Remicade, Enbrel, and Humira--indicated for arthritis and colitis and targeted to tumor necrosis factor-alpha (TNF-α), each generated over $6 billion in annual sales. In addition to TNF-α, biologic candidates targeted to other inflammatory molecules are in clinical development, partly driven by commercial interests and medical need. Although clinical experience indicates that all the anti-TNF-α molecular platforms are effective for rheumatoid arthritis, Crohn's disease, and colitis, whether the new agents can provide additional relief or cures remains to be seen." @default.
- W2037695759 created "2016-06-24" @default.
- W2037695759 creator A5045487241 @default.
- W2037695759 creator A5047922681 @default.
- W2037695759 date "2012-08-01" @default.
- W2037695759 modified "2023-10-14" @default.
- W2037695759 title "Drug Delivery Trends in Clinical Trials and Translational Medicine: Growth in Biologic Molecule Development and Impact on Rheumatoid Arthritis, Crohn's Disease, and Colitis" @default.
- W2037695759 cites W1987574056 @default.
- W2037695759 cites W2028064763 @default.
- W2037695759 cites W2042766684 @default.
- W2037695759 cites W2050690355 @default.
- W2037695759 cites W2050767393 @default.
- W2037695759 cites W2050819978 @default.
- W2037695759 cites W2085318733 @default.
- W2037695759 cites W2105585557 @default.
- W2037695759 cites W2143548516 @default.
- W2037695759 cites W2149374690 @default.
- W2037695759 doi "https://doi.org/10.1002/jps.23154" @default.
- W2037695759 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4826476" @default.
- W2037695759 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22573521" @default.
- W2037695759 hasPublicationYear "2012" @default.
- W2037695759 type Work @default.
- W2037695759 sameAs 2037695759 @default.
- W2037695759 citedByCount "13" @default.
- W2037695759 countsByYear W20376957592012 @default.
- W2037695759 countsByYear W20376957592013 @default.
- W2037695759 countsByYear W20376957592014 @default.
- W2037695759 countsByYear W20376957592015 @default.
- W2037695759 countsByYear W20376957592016 @default.
- W2037695759 countsByYear W20376957592018 @default.
- W2037695759 crossrefType "journal-article" @default.
- W2037695759 hasAuthorship W2037695759A5045487241 @default.
- W2037695759 hasAuthorship W2037695759A5047922681 @default.
- W2037695759 hasBestOaLocation W20376957592 @default.
- W2037695759 hasConcept C126322002 @default.
- W2037695759 hasConcept C142724271 @default.
- W2037695759 hasConcept C150903083 @default.
- W2037695759 hasConcept C162264550 @default.
- W2037695759 hasConcept C171250308 @default.
- W2037695759 hasConcept C177713679 @default.
- W2037695759 hasConcept C192562407 @default.
- W2037695759 hasConcept C2777138892 @default.
- W2037695759 hasConcept C2777575956 @default.
- W2037695759 hasConcept C2779134260 @default.
- W2037695759 hasConcept C2779820397 @default.
- W2037695759 hasConcept C2780035454 @default.
- W2037695759 hasConcept C2781047461 @default.
- W2037695759 hasConcept C2908701176 @default.
- W2037695759 hasConcept C535046627 @default.
- W2037695759 hasConcept C64903051 @default.
- W2037695759 hasConcept C71924100 @default.
- W2037695759 hasConcept C86803240 @default.
- W2037695759 hasConcept C98274493 @default.
- W2037695759 hasConceptScore W2037695759C126322002 @default.
- W2037695759 hasConceptScore W2037695759C142724271 @default.
- W2037695759 hasConceptScore W2037695759C150903083 @default.
- W2037695759 hasConceptScore W2037695759C162264550 @default.
- W2037695759 hasConceptScore W2037695759C171250308 @default.
- W2037695759 hasConceptScore W2037695759C177713679 @default.
- W2037695759 hasConceptScore W2037695759C192562407 @default.
- W2037695759 hasConceptScore W2037695759C2777138892 @default.
- W2037695759 hasConceptScore W2037695759C2777575956 @default.
- W2037695759 hasConceptScore W2037695759C2779134260 @default.
- W2037695759 hasConceptScore W2037695759C2779820397 @default.
- W2037695759 hasConceptScore W2037695759C2780035454 @default.
- W2037695759 hasConceptScore W2037695759C2781047461 @default.
- W2037695759 hasConceptScore W2037695759C2908701176 @default.
- W2037695759 hasConceptScore W2037695759C535046627 @default.
- W2037695759 hasConceptScore W2037695759C64903051 @default.
- W2037695759 hasConceptScore W2037695759C71924100 @default.
- W2037695759 hasConceptScore W2037695759C86803240 @default.
- W2037695759 hasConceptScore W2037695759C98274493 @default.
- W2037695759 hasIssue "8" @default.
- W2037695759 hasLocation W20376957591 @default.
- W2037695759 hasLocation W20376957592 @default.
- W2037695759 hasLocation W20376957593 @default.
- W2037695759 hasLocation W20376957594 @default.
- W2037695759 hasOpenAccess W2037695759 @default.
- W2037695759 hasPrimaryLocation W20376957591 @default.
- W2037695759 hasRelatedWork W1978193812 @default.
- W2037695759 hasRelatedWork W2071750285 @default.
- W2037695759 hasRelatedWork W2138703489 @default.
- W2037695759 hasRelatedWork W2145184504 @default.
- W2037695759 hasRelatedWork W2185871722 @default.
- W2037695759 hasRelatedWork W2521298216 @default.
- W2037695759 hasRelatedWork W2583183927 @default.
- W2037695759 hasRelatedWork W2903580296 @default.
- W2037695759 hasRelatedWork W2951006175 @default.
- W2037695759 hasRelatedWork W2967061131 @default.
- W2037695759 hasVolume "101" @default.
- W2037695759 isParatext "false" @default.
- W2037695759 isRetracted "false" @default.
- W2037695759 magId "2037695759" @default.
- W2037695759 workType "article" @default.