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• W2037699490 abstract "LettersDecember 17, 2013Vitamin D and Calcium Supplementation to Prevent Fractures in AdultsToshihiro Sugiyama, MD, PhDToshihiro Sugiyama, MD, PhDFrom Yamaguchi University School of Medicine, Yamaguchi, Japan.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-12-201312170-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The guideline from the U.S. Preventive Services Task Force (USPSTF) (1) concludes that the current evidence about calcium and vitamin D supplementation to prevent fractures in adults is essentially insufficient. This statement may be partly based on the limited efficacy of calcium and vitamin D supplementation in preventing fractures from skeletal adaptation to mechanical loading, although vitamin D promotes calcium absorption in the gut and supports bone mineralization that is essential for skeletal stiffness.Bone responds to the local mechanical environment at each skeletal site, as evidenced by marked bone gain in the dominant arms of professional ...References1. Moyer VA; U.S. Preventive Services Task Force. Vitamin D and calcium supplementation to prevent fractures in adults: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2013;158:691-6 LinkGoogle Scholar2. Sugiyama T, Meakin LB, Browne WJ, Galea GL, Price JS, and Lanyon LE. Bones' adaptive response to mechanical loading is essentially linear between the low strains associated with disuse and the high strains associated with the lamellar/woven bone transition. J Bone Miner Res. 2012;27:1784-93. [PMID: 22431329] CrossrefMedlineGoogle Scholar3. Ellman R, Spatz J, Cloutier A, Palme R, Christiansen BA, and Bouxsein ML. Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass. J Bone Miner Res. 2013;28:875-85. [PMID: 23165526] CrossrefMedlineGoogle Scholar4. Schulte FA, Ruffoni D, Lambers FM, Christen D, Webster DJ, Kuhn G, et al. Local mechanical stimuli regulate bone formation and resorption in mice at the tissue level. PLoS One. 2013;8:62172. [PMID: 23637993] CrossrefMedlineGoogle Scholar5. Vainionpää A, Korpelainen R, Vihriälä E, Rinta-Paavola A, Leppäluoto J, and Jämsä T. Intensity of exercise is associated with bone density change in premenopausal women. Osteoporos Int. 2006;17:455-63. [PMID: 16404492] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Yamaguchi University School of Medicine, Yamaguchi, Japan.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoVitamin D and Calcium Supplementation to Prevent Fractures in Adults: U.S. Preventive Services Task Force Recommendation Statement Virginia A. Moyer and Vitamin D and Calcium Supplementation to Prevent Fractures in Adults Marcus M. Reidenberg Vitamin D and Calcium Supplementation to Prevent Fractures in Adults Virginia A. Moyer , Michael L. LeFevre , and Albert L. Siu Metrics Cited ByTreatment of Low Bone Density or Osteoporosis to Prevent Fractures in Men and WomenToshihiro Sugiyama, MD, PhD December 17, 2013Volume 159, Issue 12Page: 856KeywordsBoneBone densityBone resorptionCalciumDrugsExerciseNutrientsOsteoporosisSkeletonStiffnessVitamin D ePublished: 17 December 2013 Issue Published: December 17, 2013 CopyrightCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ..." @default.
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