Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037699901> ?p ?o ?g. }
- W2037699901 endingPage "E237" @default.
- W2037699901 startingPage "E227" @default.
- W2037699901 abstract "Altered cardiac structure and function have been reported in prediabetic and diabetic populations; however, the contribution of the sympathetic nervous system (SNS) to these changes has yet to be delineated. Our objective was to examine interrelationships between glucose metabolism, left ventricular mass and function, and SNS activity in obese metabolic syndrome subjects. Unmedicated impaired glucose tolerant (IGT) (n = 31) or treatment-naive type 2 diabetic (T2D) (n = 25) subjects, matched for age (mean 58 ± 1 years), gender, body mass index (32.2 ± 0.5 kg/m2), and blood pressure, participated. They underwent echocardiography and assessments of whole-body norepinephrine kinetics, muscle sympathetic nerve activity, and insulin sensitivity by euglycemic clamp (M value). T2D subjects had higher left ventricular mass index (LVMI) (93.6 ± 3.5 vs 77.2 ± 3.4 g/m2, P = .002) and Doppler-derived isovolumetric relaxation and deceleration times (both P < .05) and lower early/late transmitral inflow velocities (E/A) (P = .02) compared with IGT. Total muscle sympathetic nerve activity and arterial norepinephrine concentration were higher in the T2D group (by 18% and 32%, respectively, both P ≤ .05), whereas plasma norepinephrine clearance was reduced (1.94 ± 0.11 vs 2.26 ± 0.10 L/min, P = .02). M value correlated inversely with left ventricular septal thickness (r = −0.46, P = .007). Whole-body noradrenaline spillover rate correlated with LVMI in the T2D subgroup (r = 0.47, P = .03). In the pooled cohort, LVMI was independently predicted by pulse pressure (r = 0.38, P = .004) and E/A ratio by 2-hour glucose (r = −0.38, P = .005). Transition from IGT to T2D is associated with cardiac enlargement and diastolic dysfunction, which relate to metabolic, hemodynamic, and SNS alterations." @default.
- W2037699901 created "2016-06-24" @default.
- W2037699901 creator A5001236718 @default.
- W2037699901 creator A5002215194 @default.
- W2037699901 creator A5011936487 @default.
- W2037699901 creator A5014744580 @default.
- W2037699901 creator A5025071539 @default.
- W2037699901 creator A5029963874 @default.
- W2037699901 creator A5047370873 @default.
- W2037699901 creator A5051342909 @default.
- W2037699901 creator A5063295354 @default.
- W2037699901 creator A5070035519 @default.
- W2037699901 creator A5083373285 @default.
- W2037699901 creator A5086606783 @default.
- W2037699901 creator A5089845194 @default.
- W2037699901 date "2013-02-01" @default.
- W2037699901 modified "2023-10-06" @default.
- W2037699901 title "The Relation of Glucose Metabolism to Left Ventricular Mass and Function and Sympathetic Nervous System Activity in Obese Subjects With Metabolic Syndrome" @default.
- W2037699901 cites W1512135595 @default.
- W2037699901 cites W1966150597 @default.
- W2037699901 cites W1977001646 @default.
- W2037699901 cites W19770870 @default.
- W2037699901 cites W1982428137 @default.
- W2037699901 cites W1995934832 @default.
- W2037699901 cites W2002619263 @default.
- W2037699901 cites W2006116370 @default.
- W2037699901 cites W2019494198 @default.
- W2037699901 cites W2020512380 @default.
- W2037699901 cites W2021515337 @default.
- W2037699901 cites W2036817503 @default.
- W2037699901 cites W2037727132 @default.
- W2037699901 cites W2041691782 @default.
- W2037699901 cites W2052306524 @default.
- W2037699901 cites W2056526409 @default.
- W2037699901 cites W2056719071 @default.
- W2037699901 cites W2070269016 @default.
- W2037699901 cites W2080205372 @default.
- W2037699901 cites W2092188043 @default.
- W2037699901 cites W2101099004 @default.
- W2037699901 cites W2101508556 @default.
- W2037699901 cites W2105912552 @default.
- W2037699901 cites W2109124852 @default.
- W2037699901 cites W2126628400 @default.
- W2037699901 cites W2130172549 @default.
- W2037699901 cites W2137890984 @default.
- W2037699901 cites W2139640181 @default.
- W2037699901 cites W2140595638 @default.
- W2037699901 cites W2143104968 @default.
- W2037699901 cites W2153454097 @default.
- W2037699901 cites W2157049654 @default.
- W2037699901 cites W2160234571 @default.
- W2037699901 cites W2161659925 @default.
- W2037699901 cites W2166162004 @default.
- W2037699901 cites W2169659546 @default.
- W2037699901 cites W2170949913 @default.
- W2037699901 cites W2324140858 @default.
- W2037699901 cites W2416839685 @default.
- W2037699901 cites W3022179669 @default.
- W2037699901 doi "https://doi.org/10.1210/jc.2012-3277" @default.
- W2037699901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23271752" @default.
- W2037699901 hasPublicationYear "2013" @default.
- W2037699901 type Work @default.
- W2037699901 sameAs 2037699901 @default.
- W2037699901 citedByCount "21" @default.
- W2037699901 countsByYear W20376999012014 @default.
- W2037699901 countsByYear W20376999012015 @default.
- W2037699901 countsByYear W20376999012016 @default.
- W2037699901 countsByYear W20376999012017 @default.
- W2037699901 countsByYear W20376999012018 @default.
- W2037699901 countsByYear W20376999012019 @default.
- W2037699901 countsByYear W20376999012020 @default.
- W2037699901 countsByYear W20376999012021 @default.
- W2037699901 countsByYear W20376999012022 @default.
- W2037699901 countsByYear W20376999012023 @default.
- W2037699901 crossrefType "journal-article" @default.
- W2037699901 hasAuthorship W2037699901A5001236718 @default.
- W2037699901 hasAuthorship W2037699901A5002215194 @default.
- W2037699901 hasAuthorship W2037699901A5011936487 @default.
- W2037699901 hasAuthorship W2037699901A5014744580 @default.
- W2037699901 hasAuthorship W2037699901A5025071539 @default.
- W2037699901 hasAuthorship W2037699901A5029963874 @default.
- W2037699901 hasAuthorship W2037699901A5047370873 @default.
- W2037699901 hasAuthorship W2037699901A5051342909 @default.
- W2037699901 hasAuthorship W2037699901A5063295354 @default.
- W2037699901 hasAuthorship W2037699901A5070035519 @default.
- W2037699901 hasAuthorship W2037699901A5083373285 @default.
- W2037699901 hasAuthorship W2037699901A5086606783 @default.
- W2037699901 hasAuthorship W2037699901A5089845194 @default.
- W2037699901 hasBestOaLocation W20376999011 @default.
- W2037699901 hasConcept C126322002 @default.
- W2037699901 hasConcept C134018914 @default.
- W2037699901 hasConcept C164705383 @default.
- W2037699901 hasConcept C2776533406 @default.
- W2037699901 hasConcept C2780221984 @default.
- W2037699901 hasConcept C39078644 @default.
- W2037699901 hasConcept C57900726 @default.
- W2037699901 hasConcept C71924100 @default.
- W2037699901 hasConcept C84393581 @default.