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- W2037701234 abstract "To address genetic influences on hippocampal neurogenesis in adult mice, we compared C57BL/6, BALB/c, CD1(ICR), and 129Sv/J mice to examine proliferation, survival, and differentiation of newborn cells in the dentate gyrus. Proliferation was highest in C57BL/6; the survival rate of newborn cells was highest in CD1. In all strains ≈60% of surviving newborn cells had a neuronal phenotype, but 129/SvJ produced more astrocytes. Over 6 days C57BL/6 produced 0.36% of their total granule cell number of 239,000 as new neurons, BALB/c 0.30% of 242,000, CD1 (ICR) 0.32% of 351,000, and 129/SvJ 0.16% of 280,000. These results show that different aspects of adult hippocampal neurogenesis are differentially influenced by the genetic background." @default.
- W2037701234 created "2016-06-24" @default.
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- W2037701234 date "1997-09-16" @default.
- W2037701234 modified "2023-10-16" @default.
- W2037701234 title "Genetic influence on neurogenesis in the dentate gyrus of adult mice" @default.
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- W2037701234 doi "https://doi.org/10.1073/pnas.94.19.10409" @default.
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