Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037701255> ?p ?o ?g. }
- W2037701255 endingPage "385" @default.
- W2037701255 startingPage "379" @default.
- W2037701255 abstract "microRNAs control synaptic signaling through regulation of postsynaptic responsiveness. This study provides evidence that the conserved microRNAs miR-1000 and miR-137 act presynaptically via glutamate transporters to regulate glutamate release. miR-1000 expression is activity dependent, perhaps allowing activity to fine-tune the strength of excitatory synaptic transmission. Evidence has begun to emerge for microRNAs as regulators of synaptic signaling, specifically acting to control postsynaptic responsiveness during synaptic transmission. In this report, we provide evidence that Drosophila melanogaster miR-1000 acts presynaptically to regulate glutamate release at the synapse by controlling expression of the vesicular glutamate transporter (VGlut). Genetic deletion of miR-1000 led to elevated apoptosis in the brain as a result of glutamatergic excitotoxicity. The seed-similar miR-137 regulated VGluT2 expression in mouse neurons. These conserved miRNAs share a neuroprotective function in the brains of flies and mice. Drosophila miR-1000 showed activity-dependent expression, which might serve as a mechanism to allow neuronal activity to fine-tune the strength of excitatory synaptic transmission." @default.
- W2037701255 created "2016-06-24" @default.
- W2037701255 creator A5005228782 @default.
- W2037701255 creator A5012778514 @default.
- W2037701255 creator A5036480188 @default.
- W2037701255 creator A5049451041 @default.
- W2037701255 creator A5067307589 @default.
- W2037701255 date "2015-02-02" @default.
- W2037701255 modified "2023-10-01" @default.
- W2037701255 title "A neuroprotective role for microRNA miR-1000 mediated by limiting glutamate excitotoxicity" @default.
- W2037701255 cites W1491963713 @default.
- W2037701255 cites W1518185094 @default.
- W2037701255 cites W1967408983 @default.
- W2037701255 cites W1968300632 @default.
- W2037701255 cites W1970994012 @default.
- W2037701255 cites W1979612171 @default.
- W2037701255 cites W1981111142 @default.
- W2037701255 cites W1983832181 @default.
- W2037701255 cites W1988499718 @default.
- W2037701255 cites W1995111140 @default.
- W2037701255 cites W1997252714 @default.
- W2037701255 cites W1999032208 @default.
- W2037701255 cites W2004390998 @default.
- W2037701255 cites W2008351358 @default.
- W2037701255 cites W2016293036 @default.
- W2037701255 cites W2018438969 @default.
- W2037701255 cites W2019028138 @default.
- W2037701255 cites W2025902983 @default.
- W2037701255 cites W2032541433 @default.
- W2037701255 cites W2035675788 @default.
- W2037701255 cites W2046930479 @default.
- W2037701255 cites W2048630757 @default.
- W2037701255 cites W2054606131 @default.
- W2037701255 cites W2055103272 @default.
- W2037701255 cites W2058705324 @default.
- W2037701255 cites W2062890651 @default.
- W2037701255 cites W2063771096 @default.
- W2037701255 cites W2075321032 @default.
- W2037701255 cites W2092356280 @default.
- W2037701255 cites W2095080219 @default.
- W2037701255 cites W2104919785 @default.
- W2037701255 cites W2120522615 @default.
- W2037701255 cites W2129692964 @default.
- W2037701255 cites W2137932411 @default.
- W2037701255 cites W2138473891 @default.
- W2037701255 cites W2149437655 @default.
- W2037701255 cites W2153213393 @default.
- W2037701255 cites W2155542046 @default.
- W2037701255 cites W2161527093 @default.
- W2037701255 cites W2162993917 @default.
- W2037701255 cites W239529647 @default.
- W2037701255 cites W2919705191 @default.
- W2037701255 cites W4295934100 @default.
- W2037701255 cites W4361807030 @default.
- W2037701255 doi "https://doi.org/10.1038/nn.3935" @default.
- W2037701255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25643297" @default.
- W2037701255 hasPublicationYear "2015" @default.
- W2037701255 type Work @default.
- W2037701255 sameAs 2037701255 @default.
- W2037701255 citedByCount "64" @default.
- W2037701255 countsByYear W20377012552015 @default.
- W2037701255 countsByYear W20377012552016 @default.
- W2037701255 countsByYear W20377012552017 @default.
- W2037701255 countsByYear W20377012552018 @default.
- W2037701255 countsByYear W20377012552019 @default.
- W2037701255 countsByYear W20377012552020 @default.
- W2037701255 countsByYear W20377012552021 @default.
- W2037701255 countsByYear W20377012552022 @default.
- W2037701255 countsByYear W20377012552023 @default.
- W2037701255 crossrefType "journal-article" @default.
- W2037701255 hasAuthorship W2037701255A5005228782 @default.
- W2037701255 hasAuthorship W2037701255A5012778514 @default.
- W2037701255 hasAuthorship W2037701255A5036480188 @default.
- W2037701255 hasAuthorship W2037701255A5049451041 @default.
- W2037701255 hasAuthorship W2037701255A5067307589 @default.
- W2037701255 hasBestOaLocation W20377012552 @default.
- W2037701255 hasConcept C112592302 @default.
- W2037701255 hasConcept C127445978 @default.
- W2037701255 hasConcept C130316041 @default.
- W2037701255 hasConcept C148785051 @default.
- W2037701255 hasConcept C169760540 @default.
- W2037701255 hasConcept C170493617 @default.
- W2037701255 hasConcept C17077164 @default.
- W2037701255 hasConcept C197341189 @default.
- W2037701255 hasConcept C200170125 @default.
- W2037701255 hasConcept C25498285 @default.
- W2037701255 hasConcept C2780648746 @default.
- W2037701255 hasConcept C2781012912 @default.
- W2037701255 hasConcept C41625074 @default.
- W2037701255 hasConcept C54355233 @default.
- W2037701255 hasConcept C61174792 @default.
- W2037701255 hasConcept C86803240 @default.
- W2037701255 hasConcept C95444343 @default.
- W2037701255 hasConceptScore W2037701255C112592302 @default.
- W2037701255 hasConceptScore W2037701255C127445978 @default.
- W2037701255 hasConceptScore W2037701255C130316041 @default.
- W2037701255 hasConceptScore W2037701255C148785051 @default.
- W2037701255 hasConceptScore W2037701255C169760540 @default.