FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037701306> ?p ?o ?g. }

• W2037701306 endingPage "1139" @default.
• W2037701306 startingPage "1128" @default.
• W2037701306 abstract "Background aims Several studies have demonstrated that the immunogenicity of chronic lymphocytic leukemia (CLL) cells can be increased by manipulation of the CD40/CD40-ligand (CD40L) pathway. Although immunologic, and perhaps clinical, benefits have been obtained with an autologous CLL tumor vaccine obtained by transgenic expression of CD40L and interleukin (IL)-2, there is little information about the optimal gene transfer strategies. Methods We compared two different CLL vaccines prepared by adenoviral gene transfer and plasmid electroporation, analyzing their phenotype and immunostimulatory activity. Results We found that higher expression of transgenic CD40L was mediated by adenoviral gene transfer than by plasmid transduction, and that adenoviral transfer of CD40L was associated with up-regulation of the co-stimulatory molecules CD80 and CD86 and adhesion molecule CD54. In contrast, transgenic IL-2 secretion was greater following plasmid transduction. These phenotypic differences in the vaccines were associated with different functionality, both ex vivo and following administration to patients. Thus adenoviral vaccines induced greater activation of leukemia-reactive T cells ex vivo than plasmid vaccines. In treated patients, specific T-cell (T helper 1 (Th1) and T helper 2 (Th2)) and humoral anti-leukemia responses were detected following administration of the adenoviral vaccine (n = 15), while recipients of the plasmid vaccine (n = 9) manifested only a low-level Th2 response. Progression-free survival at 2 years was 46.7% in the adenoviral vaccine recipients, versus 11.1 % in those receiving plasmid vaccine. Conclusions CLL vaccines expressing the same transgenes but produced by distinct methods of gene transfer may differ in the polarity of the immune response they induce in patients." @default.
• W2037701306 created "2016-06-24" @default.
• W2037701306 creator A5008386087 @default.
• W2037701306 creator A5021029688 @default.
• W2037701306 creator A5021463288 @default.
• W2037701306 creator A5023649972 @default.
• W2037701306 creator A5046029876 @default.
• W2037701306 creator A5049862423 @default.
• W2037701306 creator A5058287032 @default.
• W2037701306 creator A5060968083 @default.
• W2037701306 creator A5072815973 @default.
• W2037701306 creator A5082887496 @default.
• W2037701306 creator A5087049880 @default.
• W2037701306 date "2011-10-01" @default.
• W2037701306 modified "2023-09-28" @default.
• W2037701306 title "Comparison of two CD40-ligand/interleukin-2 vaccines in patients with chronic lymphocytic leukemia" @default.
• W2037701306 cites W185283559 @default.
• W2037701306 cites W1971487921 @default.
• W2037701306 cites W1975651897 @default.
• W2037701306 cites W1990207470 @default.
• W2037701306 cites W1993771588 @default.
• W2037701306 cites W1993986769 @default.
• W2037701306 cites W2014622437 @default.
• W2037701306 cites W2022318639 @default.
• W2037701306 cites W2048914173 @default.
• W2037701306 cites W2049547199 @default.
• W2037701306 cites W2051708207 @default.
• W2037701306 cites W2059578322 @default.
• W2037701306 cites W2076874513 @default.
• W2037701306 cites W2097240137 @default.
• W2037701306 cites W2097729403 @default.
• W2037701306 cites W2101746842 @default.
• W2037701306 cites W2108278854 @default.
• W2037701306 cites W2118184788 @default.
• W2037701306 cites W2148461908 @default.
• W2037701306 cites W2154294188 @default.
• W2037701306 cites W2228874111 @default.
• W2037701306 cites W2345971816 @default.
• W2037701306 cites W2560160217 @default.
• W2037701306 cites W4239989513 @default.
• W2037701306 cites W63353745 @default.
• W2037701306 cites W68180527 @default.
• W2037701306 cites W899734449 @default.
• W2037701306 doi "https://doi.org/10.3109/14653249.2011.592523" @default.
• W2037701306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3687103" @default.
• W2037701306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21745159" @default.
• W2037701306 hasPublicationYear "2011" @default.
• W2037701306 type Work @default.
• W2037701306 sameAs 2037701306 @default.
• W2037701306 citedByCount "14" @default.
• W2037701306 countsByYear W20377013062012 @default.
• W2037701306 countsByYear W20377013062014 @default.
• W2037701306 countsByYear W20377013062015 @default.
• W2037701306 countsByYear W20377013062016 @default.
• W2037701306 countsByYear W20377013062017 @default.
• W2037701306 countsByYear W20377013062019 @default.
• W2037701306 countsByYear W20377013062021 @default.
• W2037701306 countsByYear W20377013062022 @default.
• W2037701306 crossrefType "journal-article" @default.
• W2037701306 hasAuthorship W2037701306A5008386087 @default.
• W2037701306 hasAuthorship W2037701306A5021029688 @default.
• W2037701306 hasAuthorship W2037701306A5021463288 @default.
• W2037701306 hasAuthorship W2037701306A5023649972 @default.
• W2037701306 hasAuthorship W2037701306A5046029876 @default.
• W2037701306 hasAuthorship W2037701306A5049862423 @default.
• W2037701306 hasAuthorship W2037701306A5058287032 @default.
• W2037701306 hasAuthorship W2037701306A5060968083 @default.
• W2037701306 hasAuthorship W2037701306A5072815973 @default.
• W2037701306 hasAuthorship W2037701306A5082887496 @default.
• W2037701306 hasAuthorship W2037701306A5087049880 @default.
• W2037701306 hasBestOaLocation W20377013062 @default.
• W2037701306 hasConcept C102230213 @default.
• W2037701306 hasConcept C104317684 @default.
• W2037701306 hasConcept C111599444 @default.
• W2037701306 hasConcept C147483822 @default.
• W2037701306 hasConcept C15152581 @default.
• W2037701306 hasConcept C154317977 @default.
• W2037701306 hasConcept C159047783 @default.
• W2037701306 hasConcept C202751555 @default.
• W2037701306 hasConcept C203014093 @default.
• W2037701306 hasConcept C2776090121 @default.
• W2037701306 hasConcept C2777938653 @default.
• W2037701306 hasConcept C2778297628 @default.
• W2037701306 hasConcept C2778461978 @default.
• W2037701306 hasConcept C2780868878 @default.
• W2037701306 hasConcept C2781101188 @default.
• W2037701306 hasConcept C39347974 @default.
• W2037701306 hasConcept C502942594 @default.
• W2037701306 hasConcept C55493867 @default.
• W2037701306 hasConcept C86803240 @default.
• W2037701306 hasConcept C8891405 @default.
• W2037701306 hasConceptScore W2037701306C102230213 @default.
• W2037701306 hasConceptScore W2037701306C104317684 @default.
• W2037701306 hasConceptScore W2037701306C111599444 @default.
• W2037701306 hasConceptScore W2037701306C147483822 @default.
• W2037701306 hasConceptScore W2037701306C15152581 @default.
• W2037701306 hasConceptScore W2037701306C154317977 @default.
• W2037701306 hasConceptScore W2037701306C159047783 @default.

• next