FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037702443> ?p ?o ?g. }

• W2037702443 endingPage "1343" @default.
• W2037702443 startingPage "1333" @default.
• W2037702443 abstract "A chronic form of myopathy has been described in alcoholics, characterized by atrophy of type II fibers, due both to reduced protein synthesis and increased protein breakdown. Increased production of reactive oxygen species could probably play a role in increased protein breakdown. In addition, treatment with zinc might be beneficial, since it acts as a cofactor of several enzymes involved in the synthesis of proteins and antioxidants as copper-zinc-superoxidedismutase (SOD) and selenium dependent glutathione peroxidase (GPX). Based on these facts, we analyze the relative and combined effects of ethanol, protein malnutrition and treatment with zinc, 227 mg/l in form of zinc sulphate, on muscle changes in 8 groups of adult Sprague-Dawley rats fed following the Lieber-de Carli model during 5 weeks. We also study the association between muscle histological changes and the activity of GPX, SOD and lipid peroxidation products (MDA), with hormones such as IGF-1, and with trace elements involved in antioxidant systems and/or in lipid peroxidation, such as selenium, copper, zinc, and iron. We found type IIa and IIb fiber atrophy in the alcoholic animals, especially in the low-protein fed ones. This effect was mainly due to protein deficiency. Zinc played no role at all. Muscle iron increased in ethanol, low protein fed rats, either with or without zinc, and was directly related with muscle MDA levels, which in turn were related with muscle atrophy, as was also found for serum IGF-1 levels. Ethanol was the main responsible for all these changes, although protein undernutrition also played an independent role in MDA levels. A positive interaction between ethanol and protein deficiency on serum IGF-1 was also detected. These results suggest that both protein deficiency and ethanol contribute to muscle atrophy observed in alcoholized rats; this atrophy is associated with increased lipid peroxidation and muscle iron overload. Treatment with zinc sulphate confers no benefit." @default.
• W2037702443 created "2016-06-24" @default.
• W2037702443 creator A5010221708 @default.
• W2037702443 creator A5015126977 @default.
• W2037702443 creator A5016214125 @default.
• W2037702443 creator A5023407323 @default.
• W2037702443 creator A5040585110 @default.
• W2037702443 creator A5063495274 @default.
• W2037702443 creator A5069623063 @default.
• W2037702443 creator A5080823020 @default.
• W2037702443 date "2005-09-01" @default.
• W2037702443 modified "2023-09-27" @default.
• W2037702443 title "Alcoholic myopathy: Lack of effect of zinc supplementation" @default.
• W2037702443 cites W1485577181 @default.
• W2037702443 cites W1545281920 @default.
• W2037702443 cites W1585866115 @default.
• W2037702443 cites W1675199507 @default.
• W2037702443 cites W1902562562 @default.
• W2037702443 cites W1974236856 @default.
• W2037702443 cites W1993683028 @default.
• W2037702443 cites W1998617594 @default.
• W2037702443 cites W1999956739 @default.
• W2037702443 cites W2000725269 @default.
• W2037702443 cites W2003826796 @default.
• W2037702443 cites W2006071750 @default.
• W2037702443 cites W2010681387 @default.
• W2037702443 cites W2021046633 @default.
• W2037702443 cites W2022280130 @default.
• W2037702443 cites W2024946243 @default.
• W2037702443 cites W2028710934 @default.
• W2037702443 cites W2035872045 @default.
• W2037702443 cites W2036689746 @default.
• W2037702443 cites W2042641741 @default.
• W2037702443 cites W2046893445 @default.
• W2037702443 cites W2049850213 @default.
• W2037702443 cites W2051151986 @default.
• W2037702443 cites W2055904472 @default.
• W2037702443 cites W2060355445 @default.
• W2037702443 cites W2065929239 @default.
• W2037702443 cites W2072939657 @default.
• W2037702443 cites W2079307090 @default.
• W2037702443 cites W2084789228 @default.
• W2037702443 cites W2084944440 @default.
• W2037702443 cites W2095002208 @default.
• W2037702443 cites W2096097124 @default.
• W2037702443 cites W2098021315 @default.
• W2037702443 cites W2115152289 @default.
• W2037702443 cites W2115573890 @default.
• W2037702443 cites W2123831833 @default.
• W2037702443 cites W2141996074 @default.
• W2037702443 cites W2152435157 @default.
• W2037702443 cites W2156297698 @default.
• W2037702443 cites W2159938507 @default.
• W2037702443 cites W2160801027 @default.
• W2037702443 cites W2170553904 @default.
• W2037702443 cites W2180665841 @default.
• W2037702443 cites W2193001295 @default.
• W2037702443 cites W2341277428 @default.
• W2037702443 cites W2343468238 @default.
• W2037702443 cites W2414583096 @default.
• W2037702443 doi "https://doi.org/10.1016/j.fct.2005.03.006" @default.
• W2037702443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15869836" @default.
• W2037702443 hasPublicationYear "2005" @default.
• W2037702443 type Work @default.
• W2037702443 sameAs 2037702443 @default.
• W2037702443 citedByCount "15" @default.
• W2037702443 countsByYear W20377024432012 @default.
• W2037702443 countsByYear W20377024432014 @default.
• W2037702443 countsByYear W20377024432016 @default.
• W2037702443 countsByYear W20377024432017 @default.
• W2037702443 countsByYear W20377024432018 @default.
• W2037702443 countsByYear W20377024432019 @default.
• W2037702443 countsByYear W20377024432023 @default.
• W2037702443 crossrefType "journal-article" @default.
• W2037702443 hasAuthorship W2037702443A5010221708 @default.
• W2037702443 hasAuthorship W2037702443A5015126977 @default.
• W2037702443 hasAuthorship W2037702443A5016214125 @default.
• W2037702443 hasAuthorship W2037702443A5023407323 @default.
• W2037702443 hasAuthorship W2037702443A5040585110 @default.
• W2037702443 hasAuthorship W2037702443A5063495274 @default.
• W2037702443 hasAuthorship W2037702443A5069623063 @default.
• W2037702443 hasAuthorship W2037702443A5080823020 @default.
• W2037702443 hasConcept C126322002 @default.
• W2037702443 hasConcept C134018914 @default.
• W2037702443 hasConcept C178790620 @default.
• W2037702443 hasConcept C185592680 @default.
• W2037702443 hasConcept C2775838275 @default.
• W2037702443 hasConcept C2776263037 @default.
• W2037702443 hasConcept C2776928490 @default.
• W2037702443 hasConcept C2777300911 @default.
• W2037702443 hasConcept C2778004101 @default.
• W2037702443 hasConcept C2778760513 @default.
• W2037702443 hasConcept C2780829032 @default.
• W2037702443 hasConcept C2781172350 @default.
• W2037702443 hasConcept C535196362 @default.
• W2037702443 hasConcept C553756173 @default.
• W2037702443 hasConcept C55493867 @default.
• W2037702443 hasConcept C71924100 @default.

• next