FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037702960> ?p ?o ?g. }

• W2037702960 endingPage "258" @default.
• W2037702960 startingPage "248" @default.
• W2037702960 abstract "A series of bisazobiphenyl dyes derived from benzidine, 3-3′-dimethylbenzidine or 3,3′-dimethoxybenzidine were studied in the dog and rat. The dyes, which are commercially useful in the textile and leather industries, possess potential for metabolism to the carcinogenic aromatic amines, benzidine, 3,3′-dimethylbenzidine and 3,3′-dimethoxybenzidine via metabolic reduction of the azo bonds. Dyes were administered orally and the urine analyzed for benzidine, 3,3′-dimethyl- or 3,3′-dimethoxybenzidine using a specific gas chromatographic assay. The identity of the chromatographic peaks was confirmed by gas chromatography-mass spectrometry. Dogs treated acutely (100 mg/kg) with benzidine derived dyes excreted substantial quantities of benzidine (166–1675 μg) in urine (0–48 hr). No benzidine was detected in urine prior to treatment. Benzidine present in dog urine following dye administration exceeded by at least ninefold the benzidine present as impurity in the administered dyes and was comparable to that excreted in urine when pure benzidine was fed (100 mg/kg). Rats chronically dosed (100 mg/kg/day) with benzidine-based dyes excreted N-acetylbenzidine (3–54 μg/day) and traces of benzidine in urine. Bisazobiphenyl dyes derived from 3,3′-dimethylbenzidine and 3,3′-dimethoxybenzidine were metabolized to 3,3′-dimethyl- and 3,3′-dimethoxybenzidine, respectively, in both the dog and rat. The N-acetyl derivatives of 3,3′-dimethyl- and 3,3′-dimethoxybenzidine were identified in urine from rats treated with dyes derived from 3,3′-dimethyl- and 3,3′-dimethoxybenzidine, respectively. Results from this study indicate that the metabolic conversion of bisazobiphenyl dyes, derived from benzidine and 3,3′-dimethyl- and 3,3′-dimethoxybenzidine, to carcinogenic aromatic amines is a general phenomenon and therefore with few exceptions should be anticipated for each member of this class of chemicals." @default.
• W2037702960 created "2016-06-24" @default.
• W2037702960 creator A5090309105 @default.
• W2037702960 date "1980-11-01" @default.
• W2037702960 modified "2023-09-27" @default.
• W2037702960 title "Metabolism of bisazobiphenyl dyes derived from benzidine, 3,3?-dimethylbenzidine or 3,3?-dimethoxybenzidine to carcinogenic aromatic amines in the dog and rat*1" @default.
• W2037702960 cites W193200281 @default.
• W2037702960 cites W1970146654 @default.
• W2037702960 cites W1983018568 @default.
• W2037702960 cites W1997658027 @default.
• W2037702960 cites W2003974101 @default.
• W2037702960 cites W2007211033 @default.
• W2037702960 cites W2033439908 @default.
• W2037702960 cites W2058658264 @default.
• W2037702960 cites W2065681763 @default.
• W2037702960 cites W2088067549 @default.
• W2037702960 cites W2159458056 @default.
• W2037702960 cites W2161902543 @default.
• W2037702960 cites W2418477373 @default.
• W2037702960 doi "https://doi.org/10.1016/0041-008x(80)90296-3" @default.
• W2037702960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7466824" @default.
• W2037702960 hasPublicationYear "1980" @default.
• W2037702960 type Work @default.
• W2037702960 sameAs 2037702960 @default.
• W2037702960 citedByCount "72" @default.
• W2037702960 countsByYear W20377029602012 @default.
• W2037702960 countsByYear W20377029602015 @default.
• W2037702960 countsByYear W20377029602021 @default.
• W2037702960 crossrefType "journal-article" @default.
• W2037702960 hasAuthorship W2037702960A5090309105 @default.
• W2037702960 hasConcept C114246631 @default.
• W2037702960 hasConcept C178790620 @default.
• W2037702960 hasConcept C185592680 @default.
• W2037702960 hasConcept C2780026642 @default.
• W2037702960 hasConcept C2780267503 @default.
• W2037702960 hasConcept C43617362 @default.
• W2037702960 hasConcept C55493867 @default.
• W2037702960 hasConcept C62231903 @default.
• W2037702960 hasConceptScore W2037702960C114246631 @default.
• W2037702960 hasConceptScore W2037702960C178790620 @default.
• W2037702960 hasConceptScore W2037702960C185592680 @default.
• W2037702960 hasConceptScore W2037702960C2780026642 @default.
• W2037702960 hasConceptScore W2037702960C2780267503 @default.
• W2037702960 hasConceptScore W2037702960C43617362 @default.
• W2037702960 hasConceptScore W2037702960C55493867 @default.
• W2037702960 hasConceptScore W2037702960C62231903 @default.
• W2037702960 hasIssue "2" @default.
• W2037702960 hasLocation W20377029601 @default.
• W2037702960 hasLocation W20377029602 @default.
• W2037702960 hasOpenAccess W2037702960 @default.
• W2037702960 hasPrimaryLocation W20377029601 @default.
• W2037702960 hasRelatedWork W1997271713 @default.
• W2037702960 hasRelatedWork W2001341748 @default.
• W2037702960 hasRelatedWork W2037702960 @default.
• W2037702960 hasRelatedWork W2056025840 @default.
• W2037702960 hasRelatedWork W2100987186 @default.
• W2037702960 hasRelatedWork W2326816284 @default.
• W2037702960 hasRelatedWork W2335519493 @default.
• W2037702960 hasRelatedWork W2469823613 @default.
• W2037702960 hasRelatedWork W2896342681 @default.
• W2037702960 hasRelatedWork W3031232977 @default.
• W2037702960 hasVolume "56" @default.
• W2037702960 isParatext "false" @default.
• W2037702960 isRetracted "false" @default.
• W2037702960 magId "2037702960" @default.
• W2037702960 workType "article" @default.