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- W2037702964 abstract "To test the putative role of c-fos in F9 differentiation, we have attempted to inhibit c-fos expression in these cells using an SV40-based expression vector (pSVneo-sof) that programs expression of c-fos antisense (sof) sequences as a 3′ extension of a neo mRNA transcript. Of six G418-resistant clones isolated in transfection experiments, five expressed neo-sof transcripts. Two clones synthesized polyadenylated mRNA of the expected size (3.8 kb), two were smaller than expected, and one was larger. Two clones that expressed reduced levels of c-fos protein were inhibited in the induction of laminin, type IV collagen, and proteoglycan-19 RNA transcripts measured after 4 days of differentiation induction with RA and dibutyryl cyclic AMP. Also inhibited was the induction of the differentiation markers, TROMA-1 and TROMA-3. Antisense-expressing cells were not inhibited in the differentiation pathway to visceral endoderm since the α-fetoprotein gene was activated normally. We conclude that c-fos antisense expression inhibits some aspects of differentiation in F9 cells." @default.
- W2037702964 created "2016-06-24" @default.
- W2037702964 creator A5056962499 @default.
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- W2037702964 date "1988-09-01" @default.
- W2037702964 modified "2023-09-27" @default.
- W2037702964 title "Expression of c-fos antisense RNA inhibits the differentiation of F9 cells to parietal endoderm" @default.
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- W2037702964 doi "https://doi.org/10.1016/0012-1606(88)90164-9" @default.
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