FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037707003> ?p ?o ?g. }

• W2037707003 endingPage "1200" @default.
• W2037707003 startingPage "1195" @default.
• W2037707003 abstract "Platelet and endothelial production of nitric oxide (NO) is known to be impaired in coronary artery disease patients. Compounds that release NO (e.g. nitrates) have antiplatelet effects, but at supratherapeutic doses with hypotensive side effects.To investigate the antithrombotic effect on human blood of a novel NO donor (LA419) with known anti-ischemic properties but without hypotensive side effects and to compare with abciximab.Healthy subjects (n = 8; 32 +/- 3 years) received daily aspirin starting three days prior to the study day. Treatments (LA419 10 and 20 microm, and abciximab 4 microm) were added ex vivo to non-anticoagulated blood, and the antithrombotic properties were assessed by measuring changes in thrombus size from pretreatment baseline in the Badimon perfusion chamber at low and high shear rates. Platelet surface adhesion using a Cone and Platelet Analyzer (CPA) and platelet fibrinogen-receptor activation with flow cytometry were also evaluated.At low shear rates, LA419 displayed a reduction in thrombus area of 43% +/- 8% (10 microm) and 56% +/- 6% (20 microm), whereas at high shear rates the reductions were 44% +/- 3% (10 microm) and 62% +/- 6% (20 microm). Platelet surface adhesion with the CPA was also reduced. Abciximab exhibited a strong inhibitory effect on thrombus formation, platelet surface adhesion and fibrinogen receptor activation.The novel NO donor, LA419, shows a strong antithrombotic effect in human blood, which is comparable to abciximab, especially under high shear rate conditions. Our observations suggest that the availability of an NO donor could prove beneficial in the prevention of thrombotic complications of cardiovascular disease. Further clinical studies are warranted." @default.
• W2037707003 created "2016-06-24" @default.
• W2037707003 creator A5023236388 @default.
• W2037707003 creator A5025226913 @default.
• W2037707003 creator A5047668360 @default.
• W2037707003 creator A5073368003 @default.
• W2037707003 creator A5081257789 @default.
• W2037707003 creator A5083649982 @default.
• W2037707003 creator A5090962770 @default.
• W2037707003 date "2007-06-01" @default.
• W2037707003 modified "2023-10-16" @default.
• W2037707003 title "A novel anti‐ischemic nitric oxide donor (LA419) reduces thrombogenesis in healthy human subjects" @default.
• W2037707003 cites W1531625155 @default.
• W2037707003 cites W1981838142 @default.
• W2037707003 cites W1988803492 @default.
• W2037707003 cites W1989623429 @default.
• W2037707003 cites W1991004804 @default.
• W2037707003 cites W1994005296 @default.
• W2037707003 cites W1995320376 @default.
• W2037707003 cites W1998166048 @default.
• W2037707003 cites W2006705030 @default.
• W2037707003 cites W2007550933 @default.
• W2037707003 cites W2024004480 @default.
• W2037707003 cites W2024352468 @default.
• W2037707003 cites W2026202162 @default.
• W2037707003 cites W2028378942 @default.
• W2037707003 cites W2030923262 @default.
• W2037707003 cites W2036284239 @default.
• W2037707003 cites W2039881470 @default.
• W2037707003 cites W2045138089 @default.
• W2037707003 cites W2049364649 @default.
• W2037707003 cites W2056648903 @default.
• W2037707003 cites W2061679479 @default.
• W2037707003 cites W2073861766 @default.
• W2037707003 cites W2077401512 @default.
• W2037707003 cites W2078923850 @default.
• W2037707003 cites W2083481797 @default.
• W2037707003 cites W2092715957 @default.
• W2037707003 cites W2104380573 @default.
• W2037707003 cites W2109424852 @default.
• W2037707003 cites W2150616706 @default.
• W2037707003 cites W2154480952 @default.
• W2037707003 cites W2157524361 @default.
• W2037707003 cites W2230838014 @default.
• W2037707003 cites W2395313915 @default.
• W2037707003 cites W3022148767 @default.
• W2037707003 cites W4237399517 @default.
• W2037707003 cites W60903981 @default.
• W2037707003 doi "https://doi.org/10.1111/j.1538-7836.2007.02543.x" @default.
• W2037707003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17389007" @default.
• W2037707003 hasPublicationYear "2007" @default.
• W2037707003 type Work @default.
• W2037707003 sameAs 2037707003 @default.
• W2037707003 citedByCount "24" @default.
• W2037707003 countsByYear W20377070032013 @default.
• W2037707003 countsByYear W20377070032014 @default.
• W2037707003 countsByYear W20377070032015 @default.
• W2037707003 countsByYear W20377070032017 @default.
• W2037707003 countsByYear W20377070032018 @default.
• W2037707003 countsByYear W20377070032022 @default.
• W2037707003 crossrefType "journal-article" @default.
• W2037707003 hasAuthorship W2037707003A5023236388 @default.
• W2037707003 hasAuthorship W2037707003A5025226913 @default.
• W2037707003 hasAuthorship W2037707003A5047668360 @default.
• W2037707003 hasAuthorship W2037707003A5073368003 @default.
• W2037707003 hasAuthorship W2037707003A5081257789 @default.
• W2037707003 hasAuthorship W2037707003A5083649982 @default.
• W2037707003 hasAuthorship W2037707003A5090962770 @default.
• W2037707003 hasBestOaLocation W20377070031 @default.
• W2037707003 hasConcept C126322002 @default.
• W2037707003 hasConcept C164705383 @default.
• W2037707003 hasConcept C2776992346 @default.
• W2037707003 hasConcept C2777015399 @default.
• W2037707003 hasConcept C2777628954 @default.
• W2037707003 hasConcept C2777871224 @default.
• W2037707003 hasConcept C2779036427 @default.
• W2037707003 hasConcept C2780400711 @default.
• W2037707003 hasConcept C2781362458 @default.
• W2037707003 hasConcept C2909112448 @default.
• W2037707003 hasConcept C3018697912 @default.
• W2037707003 hasConcept C500558357 @default.
• W2037707003 hasConcept C519581460 @default.
• W2037707003 hasConcept C71924100 @default.
• W2037707003 hasConcept C89560881 @default.
• W2037707003 hasConcept C98274493 @default.
• W2037707003 hasConceptScore W2037707003C126322002 @default.
• W2037707003 hasConceptScore W2037707003C164705383 @default.
• W2037707003 hasConceptScore W2037707003C2776992346 @default.
• W2037707003 hasConceptScore W2037707003C2777015399 @default.
• W2037707003 hasConceptScore W2037707003C2777628954 @default.
• W2037707003 hasConceptScore W2037707003C2777871224 @default.
• W2037707003 hasConceptScore W2037707003C2779036427 @default.
• W2037707003 hasConceptScore W2037707003C2780400711 @default.
• W2037707003 hasConceptScore W2037707003C2781362458 @default.
• W2037707003 hasConceptScore W2037707003C2909112448 @default.
• W2037707003 hasConceptScore W2037707003C3018697912 @default.
• W2037707003 hasConceptScore W2037707003C500558357 @default.
• W2037707003 hasConceptScore W2037707003C519581460 @default.

• next